ENSDARG00000079296


Danio rerio

Features
Gene ID: ENSDARG00000079296
  
Biological name :gcga
  
Synonyms : gcga / glucagon a
  
Possible biological names infered from orthology : GCG / glucagon / Glucagon Glicentin Glicentin-related polypeptide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like peptide 2 / P01275 / P55095
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 11617520
Gene end: 11626018
  
Corresponding Affymetrix probe sets: Dr.10728.1.S1_at (Zebrafish Array)   NM_001008595_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000139130
Ensembl peptide - ENSDARP00000063132
Ensembl peptide - ENSDARP00000116629
NCBI entrez gene - 494052     See in Manteia.
RefSeq - NM_001008595
RefSeq - NM_001271770
RefSeq Peptide - NP_001008595
RefSeq Peptide - NP_001258699
swissprot - F1RD10
swissprot - A0A0R4IS85
swissprot - F1R169
ZFIN ID - ZDB-GENE-010219-1
Ensembl - ENSDARG00000079296
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000042837Gallus gallus
 GCGENSGALG00000011104Gallus gallus
 GCGENSG00000115263Homo sapiens
 GcgENSMUSG00000000394Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gcgb / glucagon b / GCG* / P01275* / P55095* / glucagon* / Glucagon Glicentin Glicentin-related polypeptide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Gluc...ENSDARG0000004090759


Protein motifs (from Interpro)
Interpro ID Name
 IPR000532  Glucagon/GIP/secretin/VIP
 IPR015550  Glucagon


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003323 type B pancreatic cell development IMP
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010737 protein kinase A signaling IBA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IBA
 biological_processGO:0042594 response to starvation IDA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0031769 glucagon receptor binding IDA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000036272 gcgrb / glucagon receptor b / GCGR* / Q61606* / P47871* / glucagon receptor*  / reaction / complex
 ENSDARG00000079420 dpp4 / dipeptidyl-peptidase 4 / FAP* / Q12884* / P27487* / P28843* / P97321* / fibroblast activation protein alpha* / Prolyl endopeptidase FAP Antiplasmin-cleaving enzyme FAP, soluble form*...  / reaction
 ENSDARG00000078468 fap / fibroblast activation protein, alpha / DPP4* / Q12884* / P27487* / P28843* / P97321* / dipeptidyl peptidase 4* / Prolyl endopeptidase FAP Antiplasmin-cleaving enzyme FAP, soluble form...  / reaction
 ENSDARG00000104022 gcgra / glucagon receptor a / GCGR* / P47871* / glucagon receptor*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr