ENSMUSG00000000394


Mus musculus

Features
Gene ID: ENSMUSG00000000394
  
Biological name :Gcg
  
Synonyms : Gcg / Glucagon Glicentin Glicentin-related polypeptide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like peptide 2 / P55095
  
Possible biological names infered from orthology : glucagon / P01275
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.3
Gene start: 62474530
Gene end: 62483650
  
Corresponding Affymetrix probe sets: 10483074 (MoGene1.0st)   1425952_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115892
Ensembl peptide - ENSMUSP00000099794
NCBI entrez gene - 14526     See in Manteia.
MGI - MGI:95674
RefSeq - NM_008100
RefSeq Peptide - NP_032126
swissprot - A2AS86
swissprot - P55095
Ensembl - ENSMUSG00000000394
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gcgaENSDARG00000079296Danio rerio
 gcgbENSDARG00000040907Danio rerio
 GCGENSGALG00000011104Gallus gallus
 GCGENSG00000115263Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000532  Glucagon/GIP/secretin/VIP
 IPR015550  Glucagon


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010737 protein kinase A signaling IMP
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
 biological_processGO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IDA
 biological_processGO:0042594 response to starvation IBA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0050796 regulation of insulin secretion IDA
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0090280 positive regulation of calcium ion import IDA
 biological_processGO:1900118 negative regulation of execution phase of apoptosis IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0031769 glucagon receptor binding IBA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005216 abnormal pancreatic alpha cell morphology "malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009108 increased pancreas weight "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009167 increased pancreatic islet number "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021587 Pcsk1 / P63239 / Neuroendocrine convertase 1 / P29120* / proprotein convertase subtilisin/kexin type 1*  / reaction
 ENSMUSG00000035000 Dpp4 / P28843 / Dipeptidyl peptidase 4 Dipeptidyl peptidase 4 membrane form Dipeptidyl peptidase 4 soluble form / P27487* / dipeptidyl peptidase 4*  / reaction
 ENSMUSG00000025127 Gcgr / Q61606 / Glucagon receptor / P47871*  / reaction / complex
 ENSMUSG00000024027 Glp1r / O35659 / Glucagon-like peptide 1 receptor / P43220*  / reaction / complex
 ENSMUSG00000027523 Gnas / Q9Z0F1 / P63094 / Q6R0H6 / Q6R0H7 / GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus / P84996* / Q5JWF2* / O95467* / P63092* / GNAS complex locus*  / reaction / complex
 ENSMUSG00000049928 Glp2r / Q5IXF8 / Glucagon-like peptide 2 receptor / O95838*  / reaction / complex






 

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