ENSG00000115263


Homo sapiens

Features
Gene ID: ENSG00000115263
  
Biological name :GCG
  
Synonyms : GCG / glucagon / P01275
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q24.2
Gene start: 162142873
Gene end: 162152404
  
Corresponding Affymetrix probe sets: 206422_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387662
Ensembl peptide - ENSP00000364647
NCBI entrez gene - 2641     See in Manteia.
OMIM - 138030
RefSeq - NM_002054
RefSeq Peptide - NP_002045
swissprot - P01275
Ensembl - ENSG00000115263
  
Related genetic diseases (OMIM): 138030 - [?Hyperproglucagonemia]
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gcgaENSDARG00000079296Danio rerio
 gcgbENSDARG00000040907Danio rerio
 GCGENSGALG00000011104Gallus gallus
 GcgENSMUSG00000000394Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000532  Glucagon/GIP/secretin/VIP
 IPR015550  Glucagon


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007631 feeding behavior TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010737 protein kinase A signaling IBA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IBA
 biological_processGO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IEA
 biological_processGO:0042594 response to starvation IBA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071377 cellular response to glucagon stimulus TAS
 biological_processGO:0090280 positive regulation of calcium ion import IEA
 biological_processGO:1900118 negative regulation of execution phase of apoptosis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0034774 secretory granule lumen TAS
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005179 hormone activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031769 glucagon receptor binding IBA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087460 GNAS / O95467 / Q5JWF2 / P63092 / P84996 / GNAS complex locus  / reaction / complex
 ENSG00000197635 DPP4 / P27487 / dipeptidyl peptidase 4  / reaction
 ENSG00000112164 GLP1R / P43220 / glucagon like peptide 1 receptor  / complex / reaction
 ENSG00000215644 GCGR / P47871 / glucagon receptor  / complex / reaction
 ENSG00000065325 GLP2R / O95838 / glucagon like peptide 2 receptor  / reaction / complex






 

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