ENSG00000197635


Homo sapiens

Features
Gene ID: ENSG00000197635
  
Biological name :DPP4
  
Synonyms : dipeptidyl peptidase 4 / DPP4 / P27487
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q24.2
Gene start: 161992241
Gene end: 162074542
  
Corresponding Affymetrix probe sets: 203716_s_at (Human Genome U133 Plus 2.0 Array)   203717_at (Human Genome U133 Plus 2.0 Array)   211478_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401359
Ensembl peptide - ENSP00000410264
Ensembl peptide - ENSP00000486421
Ensembl peptide - ENSP00000353731
Ensembl peptide - ENSP00000402259
NCBI entrez gene - 1803     See in Manteia.
OMIM - 102720
RefSeq - XM_005246371
RefSeq - NM_001935
RefSeq Peptide - NP_001926
swissprot - H7C1N5
swissprot - F8WBB6
swissprot - P27487
swissprot - F8WE17
Ensembl - ENSG00000197635
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dpp4ENSDARG00000079420Danio rerio
 fapENSDARG00000078468Danio rerio
 DPP4ENSGALG00000042452Gallus gallus
 Dpp4ENSMUSG00000035000Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FAP / Q12884 / fibroblast activation protein alphaENSG0000007809851
DPP10 / Q8N608 / dipeptidyl peptidase like 10ENSG0000017549735
DPP6 / P42658 / dipeptidyl peptidase like 6ENSG0000013022632
DPP9 / Q86TI2 / dipeptidyl peptidase 9ENSG0000014200222
DPP8 / Q6V1X1 / dipeptidyl peptidase 8ENSG0000007460322


Protein motifs (from Interpro)
Interpro ID Name
 IPR001375  Peptidase S9, prolyl oligopeptidase, catalytic domain
 IPR002469  Dipeptidylpeptidase IV, N-terminal domain
 IPR002471  Peptidase S9, serine active site
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010716 negative regulation of extracellular matrix disassembly IDA
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0033632 regulation of cell-cell adhesion mediated by integrin IDA
 biological_processGO:0035641 locomotory exploration behavior IEA
 biological_processGO:0036343 psychomotor behavior IEA
 biological_processGO:0042110 T cell activation IDA
 biological_processGO:0043542 endothelial cell migration IDA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0050796 regulation of insulin secretion TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0046581 intercellular canaliculus IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071438 invadopodium membrane IEA
 molecular_functionGO:0001618 virus receptor activity IDA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity EXP
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IDA
 molecular_functionGO:0008239 dipeptidyl-peptidase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115263 GCG / P01275 / glucagon  / reaction
 ENSG00000159224 GIP / P09681 / gastric inhibitory polypeptide  / reaction






 

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