ENSG00000159224


Homo sapiens

Features
Gene ID: ENSG00000159224
  
Biological name :GIP
  
Synonyms : gastric inhibitory polypeptide / GIP / P09681
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.32
Gene start: 48958554
Gene end: 48968596
  
Corresponding Affymetrix probe sets: 207899_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000350005
NCBI entrez gene - 2695     See in Manteia.
OMIM - 137240
RefSeq - NM_004123
RefSeq Peptide - NP_004114
swissprot - P09681
Ensembl - ENSG00000159224
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GipENSMUSG00000014351Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000532  Glucagon/GIP/secretin/VIP


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0009743 response to carbohydrate IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010269 response to selenium ion IEA
 biological_processGO:0010447 response to acidic pH IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010828 positive regulation of glucose transmembrane transport IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0035640 exploration behavior IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0050806 positive regulation of synaptic transmission IEA
 biological_processGO:0055123 digestive system development IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0070094 positive regulation of glucagon secretion IEA
 biological_processGO:0070328 triglyceride homeostasis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005179 hormone activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175426 PCSK1 / P29120 / proprotein convertase subtilisin/kexin type 1  / reaction
 ENSG00000197635 DPP4 / P27487 / dipeptidyl peptidase 4  / reaction
 ENSG00000010310 GIPR / P48546 / gastric inhibitory polypeptide receptor  / complex / reaction






 

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