ENSG00000010310


Homo sapiens

Features
Gene ID: ENSG00000010310
  
Biological name :GIPR
  
Synonyms : gastric inhibitory polypeptide receptor / GIPR / P48546
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 45668244
Gene end: 45683724
  
Corresponding Affymetrix probe sets: 208105_at (Human Genome U133 Plus 2.0 Array)   231291_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000305321
Ensembl peptide - ENSP00000467342
Ensembl peptide - ENSP00000467494
Ensembl peptide - ENSP00000263281
Ensembl peptide - ENSP00000465385
NCBI entrez gene - 2696     See in Manteia.
OMIM - 137241
RefSeq - XM_011526716
RefSeq - XM_011526710
RefSeq - XM_011526711
RefSeq - XM_011526713
RefSeq - XM_011526714
RefSeq - XM_011526715
RefSeq - NM_000164
RefSeq - NM_001308418
RefSeq - XM_011526709
RefSeq Peptide - NP_000155
RefSeq Peptide - NP_001295347
swissprot - K7EPD9
swissprot - P48546
swissprot - K7EJZ3
Ensembl - ENSG00000010310
  
Related genetic diseases (OMIM): 137241 - [Plasma glucose, 2-hour, QTL 2]
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 giprENSDARG00000025478Danio rerio
 GiprENSMUSG00000030406Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GCGR / P47871 / glucagon receptorENSG0000021564449
GLP1R / P43220 / glucagon like peptide 1 receptorENSG0000011216441
GLP2R / O95838 / glucagon like peptide 2 receptorENSG0000006532539
SCTR / P47872 / secretin receptorENSG0000008029335
PTH1R / Q03431 / parathyroid hormone 1 receptorENSG0000016080135
VIPR1 / P32241 / vasoactive intestinal peptide receptor 1ENSG0000011481234
VIPR2 / P41587 / vasoactive intestinal peptide receptor 2ENSG0000010601832
P41586 / ADCYAP1R1 / ADCYAP receptor type IENSG0000007854932
PTH2R / P49190 / parathyroid hormone 2 receptorENSG0000014440730
GHRHR / Q02643 / growth hormone releasing hormone receptorENSG0000010612827


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001749  GPCR, family 2, gastric inhibitory polypeptide receptor
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002029 desensitization of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0006091 generation of precursor metabolites and energy TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007584 response to nutrient TAS
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0038192 gastric inhibitory peptide signaling pathway IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0070542 response to fatty acid IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016519 gastric inhibitory peptide receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000159224 GIP / P09681 / gastric inhibitory polypeptide  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr