ENSG00000078549


Homo sapiens

Features
Gene ID: ENSG00000078549
  
Biological name :ADCYAP1R1
  
Synonyms : ADCYAP1R1 / ADCYAP receptor type I / P41586
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p14.3
Gene start: 31052461
Gene end: 31111479
  
Corresponding Affymetrix probe sets: 207151_at (Human Genome U133 Plus 2.0 Array)   226690_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387335
Ensembl peptide - ENSP00000386395
Ensembl peptide - ENSP00000400893
Ensembl peptide - ENSP00000483721
Ensembl peptide - ENSP00000416622
Ensembl peptide - ENSP00000306620
Ensembl peptide - ENSP00000379514
NCBI entrez gene - 117     See in Manteia.
OMIM - 102981
RefSeq - XM_017011738
RefSeq - NM_001118
RefSeq - NM_001199635
RefSeq - NM_001199636
RefSeq - NM_001199637
RefSeq - XM_005249618
RefSeq - XM_006715645
RefSeq - XM_017011736
RefSeq - XM_017011737
RefSeq Peptide - NP_001109
RefSeq Peptide - NP_001186565
RefSeq Peptide - NP_001186566
RefSeq Peptide - NP_001186564
swissprot - P41586
swissprot - A0A090N8F8
swissprot - E9PFU5
swissprot - C9JVH3
swissprot - H0Y813
Ensembl - ENSG00000078549
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcyap1r1aENSDARG00000105201Danio rerio
 adcyap1r1aENSDARG00000053724Danio rerio
 ADCYAP1R1ENSGALG00000005223Gallus gallus
 P70205ENSMUSG00000029778Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VIPR1 / P32241 / vasoactive intestinal peptide receptor 1ENSG0000011481245
VIPR2 / P41587 / vasoactive intestinal peptide receptor 2ENSG0000010601844
SCTR / P47872 / secretin receptorENSG0000008029341
GHRHR / Q02643 / growth hormone releasing hormone receptorENSG0000010612835
PTH1R / Q03431 / parathyroid hormone 1 receptorENSG0000016080133
GLP2R / O95838 / glucagon like peptide 2 receptorENSG0000006532530
GIPR / P48546 / gastric inhibitory polypeptide receptorENSG0000001031030
GCGR / P47871 / glucagon receptorENSG0000021564430
GLP1R / P43220 / glucagon like peptide 1 receptorENSG0000011216429
PTH2R / P49190 / parathyroid hormone 2 receptorENSG0000014440728


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR002285  GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033555 multicellular organismal response to stress IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046545 development of primary female sexual characteristics IEA
 biological_processGO:0051057 positive regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004999 vasoactive intestinal polypeptide receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008179 adenylate cyclase binding IEA
 molecular_functionGO:0030306 ADP-ribosylation factor binding IEA
 molecular_functionGO:0042923 neuropeptide binding IEA


Pathways (from Reactome)
Pathway description
NGF-independant TRKA activation
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / reaction / complex
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000141433 P18509 / ADCYAP1 / adenylate cyclase activating polypeptide 1  / reaction / complex






 

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