ENSG00000141433


Homo sapiens

Features
Gene ID: ENSG00000141433
  
Biological name :ADCYAP1
  
Synonyms : ADCYAP1 / adenylate cyclase activating polypeptide 1 / P18509
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: p11.32
Gene start: 904943
Gene end: 912172
  
Corresponding Affymetrix probe sets: 206281_at (Human Genome U133 Plus 2.0 Array)   230237_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411658
Ensembl peptide - ENSP00000462647
NCBI entrez gene - 116     See in Manteia.
OMIM - 102980
RefSeq - XM_005258081
RefSeq - NM_001099733
RefSeq - NM_001117
RefSeq Peptide - NP_001108
RefSeq Peptide - NP_001093203
swissprot - P18509
Ensembl - ENSG00000141433
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcyap1aENSDARG00000004015Danio rerio
 adcyap1bENSDARG00000027740Danio rerio
 ADCYAP1ENSGALG00000014858Gallus gallus
 O70176ENSMUSG00000024256Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VIP / P01282 / vasoactive intestinal peptideENSG0000014646931


Protein motifs (from Interpro)
Interpro ID Name
 IPR000532  Glucagon/GIP/secretin/VIP


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0001821 histamine secretion IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0002865 negative regulation of acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0002878 negative regulation of acute inflammatory response to non-antigenic stimulus IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007565 female pregnancy TAS
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IDA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010656 negative regulation of muscle cell apoptotic process IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0043267 negative regulation of potassium ion transport IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046034 ATP metabolic process IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060124 positive regulation of growth hormone secretion IEA
 biological_processGO:0060253 negative regulation of glial cell proliferation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070445 regulation of oligodendrocyte progenitor proliferation IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IEA
 biological_processGO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production IDA
 biological_processGO:0090274 positive regulation of somatostatin secretion IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0043195 terminal bouton IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016521 pituitary adenylate cyclase activating polypeptide activity IDA
 molecular_functionGO:0031858 pituitary adenylate cyclase-activating polypeptide receptor binding IEA
 molecular_functionGO:0051428 peptide hormone receptor binding IPI


Pathways (from Reactome)
Pathway description
NGF-independant TRKA activation
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000078549 P41586 / ADCYAP1R1 / ADCYAP receptor type I  / reaction / complex
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / reaction / complex
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction






 

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