MP:0000189 | hypoglycemia | "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)
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MP:0000759 | abnormal skeletal muscle morphology | "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0001312 | abnormal cornea morphology | "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0001314 | corneal opacity | "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0001364 | decreased anxiety-related response | "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0001377 | abnormal copulation | "reduced or absent attempt of sexual contact between a male and a receptive female " [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Trp73tm1Mak/Trp73+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Adcyap1tm1Clw/Adcyap1tm1Clw Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0001415 | increased exploration in new environment | "greater amount of time spent investigating new location" [J:28825] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0001442 | decreased grooming behavior | "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)
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MP:0001554 | increased circulating free fatty acid level | "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)
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MP:0001729 | impaired implantation | "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Adcyap1tm1Aba/Adcyap1tm1Aba Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR
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MP:0001745 | increased circulating corticosterone level | "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)
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MP:0001783 | decreased white fat amount | "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0001828 | abnormal T cell activation | "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0 Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0001921 | reduced fertility | "diminished ability to produce live offspring" [J:65030] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Adcyap1tm1Aba/Adcyap1tm1Aba Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR
Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: B6.129-Adcyap1tm1Nms
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MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Trp73tm1Mak/Trp73+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0002079 | increased circulating insulin level | "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)
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MP:0002566 | abnormal sexual interaction | "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Adcyap1tm1Aba/Adcyap1tm1Aba Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR
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MP:0002574 | increased vertical activity | "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0002575 | increased circulating ketone body level | "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)
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MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)
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MP:0003962 | abnormal adrenaline level | "aberrant concentration in the blood or tissues of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0004946 | abnormal regulatory T cell physiology | "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0 Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0005121 | decreased circulating prolactin level | "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: B6.129-Adcyap1tm1Nms
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MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)
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MP:0005185 | decreased circulating progesterone level | "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: B6.129-Adcyap1tm1Nms
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MP:0005439 | decreased glycogen level | "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)
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MP:0006000 | abnormal corneal epithelium | "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: B6.129-Adcyap1tm1Nms
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MP:0009326 | abnormal maternal crouching | "females do not assume a position over young that facilitates suckling behavior" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adcyap1tm1Aba/Adcyap1tm1Aba Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR
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MP:0010219 | increased T-helper 17 cell number | "increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899] |
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0 Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0011049 | impaired adaptive thermogenesis | "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)
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MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms Genetic Background: B6.129-Adcyap1tm1Nms
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MP:0011110 | partial preweaning lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Adcyap1tm1Clw/Adcyap1tm1Clw Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0011448 | decreased dopaminergic neuron number | "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb] |
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0 Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0011451 | increased susceptibility to dopaminergic neuron neurotoxicity | "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith] |
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0 Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0020220 | decreased tear production | "decreased production of the amount of fluid produced in the eye" [GOC:NV] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0020448 | increased microglial cell activation | "increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774] |
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0 Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0020470 | shortened circadian behavior period | "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb] |
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Allelic Composition: Adcyap1tm1Clw/Adcyap1tm1Clw Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0020473 | abnormal circadian behavior phase | "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb] |
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Allelic Composition: Adcyap1tm1Clw/Adcyap1tm1Clw Genetic Background: involves: 129S4/SvJae * C57BL/6
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