ENSMUSG00000024256


Mus musculus

Features
Gene ID: ENSMUSG00000024256
  
Biological name :Adcyap1
  
Synonyms : Adcyap1 / adenylate cyclase activating polypeptide 1 / O70176
  
Possible biological names infered from orthology : P18509
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E5
Gene start: 93199422
Gene end: 93205485
  
Corresponding Affymetrix probe sets: 10447502 (MoGene1.0st)   1423427_at (Mouse Genome 430 2.0 Array)   1441778_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067057
NCBI entrez gene - 11516     See in Manteia.
MGI - MGI:105094
RefSeq - NM_009625
RefSeq - XM_006523498
RefSeq - NM_001315503
RefSeq - NM_001315504
RefSeq Peptide - NP_001302433
RefSeq Peptide - NP_033755
RefSeq Peptide - NP_001302432
swissprot - O70176
swissprot - Q3UYH8
Ensembl - ENSMUSG00000024256
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcyap1aENSDARG00000004015Danio rerio
 adcyap1bENSDARG00000027740Danio rerio
 ADCYAP1ENSGALG00000014858Gallus gallus
 P18509ENSG00000141433Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vip / vasoactive intestinal polypeptide / P01282* / vasoactive intestinal peptide*ENSMUSG0000001977229


Protein motifs (from Interpro)
Interpro ID Name
 IPR000532  Glucagon/GIP/secretin/VIP


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0001821 histamine secretion IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0002865 negative regulation of acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0002878 negative regulation of acute inflammatory response to non-antigenic stimulus IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010656 negative regulation of muscle cell apoptotic process IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0030073 insulin secretion IDA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032880 regulation of protein localization IDA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0043267 negative regulation of potassium ion transport IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045786 negative regulation of cell cycle IDA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046034 ATP metabolic process IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060124 positive regulation of growth hormone secretion IEA
 biological_processGO:0060253 negative regulation of glial cell proliferation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070445 regulation of oligodendrocyte progenitor proliferation IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IEA
 biological_processGO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production IEA
 biological_processGO:0090274 positive regulation of somatostatin secretion IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0043195 terminal bouton IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor TAS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IEA
 molecular_functionGO:0016521 pituitary adenylate cyclase activating polypeptide activity IDA
 molecular_functionGO:0031858 pituitary adenylate cyclase-activating polypeptide receptor binding IEA
 molecular_functionGO:0051428 peptide hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp
Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp
Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001377 abnormal copulation "reduced or absent attempt of sexual contact between a male and a receptive female " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Trp73tm1Mak/Trp73+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Adcyap1tm1Clw/Adcyap1tm1Clw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001729 impaired implantation "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adcyap1tm1Aba/Adcyap1tm1Aba
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Adcyap1tm1Aba/Adcyap1tm1Aba
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: B6.129-Adcyap1tm1Nms

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp73tm1Mak/Trp73+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adcyap1tm1Aba/Adcyap1tm1Aba
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0003962 abnormal adrenaline level "aberrant concentration in the blood or tissues of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: B6.129-Adcyap1tm1Nms

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: B6.129-Adcyap1tm1Nms

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp
Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: B6.129-Adcyap1tm1Nms

 MP:0009326 abnormal maternal crouching "females do not assume a position over young that facilitates suckling behavior" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Adcyap1tm1Aba/Adcyap1tm1Aba
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

 MP:0010219 increased T-helper 17 cell number "increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nf2tm2.1Gth/Nf2tm2.1Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: B6.129-Adcyap1tm1Nms

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Adcyap1tm1Clw/Adcyap1tm1Clw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0011451 increased susceptibility to dopaminergic neuron neurotoxicity "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0020220 decreased tear production "decreased production of the amount of fluid produced in the eye" [GOC:NV]
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp
Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp

 MP:0020448 increased microglial cell activation "increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Adcyap1tm1Clw/Adcyap1tm1Clw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Adcyap1tm1Clw/Adcyap1tm1Clw
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029778 P70205 / Adcyap1r1 / adenylate cyclase activating polypeptide 1 receptor 1 / P41586* / ADCYAP receptor type I*  / complex / reaction






 

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