ENSMUSG00000019772


Mus musculus

Features
Gene ID: ENSMUSG00000019772
  
Biological name :Vip
  
Synonyms : vasoactive intestinal polypeptide / Vip
  
Possible biological names infered from orthology : P01282 / vasoactive intestinal peptide
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A1
Gene start: 5639218
Gene end: 5647617
  
Corresponding Affymetrix probe sets: 10367582 (MoGene1.0st)   1428664_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019906
NCBI entrez gene - 22353     See in Manteia.
MGI - MGI:98933
RefSeq - XM_006512448
RefSeq - NM_001313969
RefSeq - NM_011702
RefSeq - XM_006512446
RefSeq - XM_006512447
RefSeq Peptide - NP_001300898
RefSeq Peptide - NP_035832
swissprot - A0A0R4J003
Ensembl - ENSMUSG00000019772
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vipENSDARG00000078247Danio rerio
 VIPENSGALG00000013604Gallus gallus
 VIPENSG00000146469Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70176 / Adcyap1 / adenylate cyclase activating polypeptide 1 / P18509*ENSMUSG0000002425630


Protein motifs (from Interpro)
Interpro ID Name
 IPR000532  Glucagon/GIP/secretin/VIP
 IPR015523  Vasoactive intestinal peptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Ltatm1Dch/Ltatm1Dch,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Ltatm1Dch/Ltatm1Dch,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Npc1m1N/Npc1m1N
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ltatm1Dch/Ltatm1Dch,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ltatm1Dch/Ltatm1Dch,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-un+2J/Oca2p-un+2J
Genetic Background: C57BL/6J-Oca2p-un

Allelic Composition: Viptm2.1(flpo)Zjh/Viptm2.1(flpo)Zjh
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Npc1m1N/Npc1m1N
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0002782 abnormal testicular secretion "malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Npc1m1N/Npc1m1N
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Npc1m1N/Npc1m1N
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0003548 pulmonary hypertension "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]
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Allelic Composition: Ltatm1Dch/Ltatm1Dch,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltatm1Dch/Ltatm1Dch,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Npc1m1N/Npc1m1N
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0010758 increased right ventricle systolic pressure "increase in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltatm1Dch/Ltatm1Dch,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Ltatm1Dch/Ltatm1Dch,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0020472 arrhythmic circadian behavior persistence "loss of a behavioral rhythmic pattern upon removal of time cues" [MGI:smb]
Show

Allelic Composition: Ltatm1Dch/Ltatm1Dch,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
Show

Allelic Composition: Ltatm1Dch/Ltatm1Dch,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Viptm1Clw/Vip+
Genetic Background: involves: 129S/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000011171 Vipr2 / P41588 / vasoactive intestinal peptide receptor 2 / P41587*  / reaction / complex
 ENSMUSG00000032528 Vipr1 / P97751 / vasoactive intestinal peptide receptor 1 / P32241*  / complex / reaction






 

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