ENSMUSG00000032528


Mus musculus

Features
Gene ID: ENSMUSG00000032528
  
Biological name :Vipr1
  
Synonyms : P97751 / vasoactive intestinal peptide receptor 1 / Vipr1
  
Possible biological names infered from orthology : P32241
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F4
Gene start: 121642716
Gene end: 121672954
  
Corresponding Affymetrix probe sets: 10590365 (MoGene1.0st)   10590381 (MoGene1.0st)   1423004_at (Mouse Genome 430 2.0 Array)   1455555_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035115
NCBI entrez gene - 22354     See in Manteia.
MGI - MGI:109272
RefSeq - NM_011703
RefSeq - XM_006512068
RefSeq Peptide - NP_035833
swissprot - P97751
Ensembl - ENSMUSG00000032528
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vipr1aENSDARG00000028878Danio rerio
 vipr1bENSDARG00000059058Danio rerio
 VIPR1ENSGALG00000005259Gallus gallus
 VIPR1ENSG00000114812Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70205 / Adcyap1r1 / adenylate cyclase activating polypeptide 1 receptor 1 / P41586* / ADCYAP receptor type I*ENSMUSG0000002977849
Vipr2 / P41588 / vasoactive intestinal peptide receptor 2 / P41587*ENSMUSG0000001117147
Sctr / Q5FWI2 / Secretin receptor / P47872*ENSMUSG0000002638744
Glp1r / O35659 / Glucagon-like peptide 1 receptor / P43220*ENSMUSG0000002402739
Pth1r / P41593 / Parathyroid hormone/parathyroid hormone-related peptide receptor / Q03431* / parathyroid hormone 1 receptor*ENSMUSG0000003249239
Ghrhr / P32082 / Growth hormone-releasing hormone receptor / Q02643*ENSMUSG0000000465438
Pth2r / Q91V95 / Parathyroid hormone 2 receptor / P49190*ENSMUSG0000002594636
Gcgr / Q61606 / Glucagon receptor / P47871*ENSMUSG0000002512735
Gipr / Q0P543 / Gastric inhibitory polypeptide receptor / P48546*ENSMUSG0000003040635
Glp2r / Q5IXF8 / Glucagon-like peptide 2 receptor / O95838*ENSMUSG0000004992834


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001571  GPCR, family 2, vasoactive intestinal peptide receptor
 IPR001771  GPCR, family 2, vasoactive intestinal peptide receptor 1
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004999 vasoactive intestinal polypeptide receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003270 intestinal obstruction "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009476 enlarged cecum "increased size of the large sac at the ileum and large intestine junction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
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Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gata5tm1.1Nemr/Gata5tm1.1Nemr,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Vipr1tm1Dgen/Vipr1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019772 Vip / vasoactive intestinal polypeptide / P01282* / vasoactive intestinal peptide*  / complex / reaction






 

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