ENSMUSG00000032492


Mus musculus

Features
Gene ID: ENSMUSG00000032492
  
Biological name :Pth1r
  
Synonyms : P41593 / Parathyroid hormone/parathyroid hormone-related peptide receptor / Pth1r
  
Possible biological names infered from orthology : parathyroid hormone 1 receptor / Q03431
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F2
Gene start: 110722085
Gene end: 110747145
  
Corresponding Affymetrix probe sets: 10597239 (MoGene1.0st)   1417092_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142957
Ensembl peptide - ENSMUSP00000142672
Ensembl peptide - ENSMUSP00000143298
Ensembl peptide - ENSMUSP00000143470
Ensembl peptide - ENSMUSP00000006005
Ensembl peptide - ENSMUSP00000132064
NCBI entrez gene - 19228     See in Manteia.
MGI - MGI:97801
RefSeq - XM_017313215
RefSeq - NM_001083936
RefSeq - NM_011199
RefSeq - XM_006511985
RefSeq - XM_006511987
RefSeq - XM_006511988
RefSeq - XM_011242942
RefSeq - XM_017313214
RefSeq - NM_001083935
RefSeq Peptide - NP_035329
RefSeq Peptide - NP_001077404
RefSeq Peptide - NP_001077405
swissprot - A0A0G2JE85
swissprot - P41593
swissprot - A0A0G2JEZ1
swissprot - A0A0G2JG89
Ensembl - ENSMUSG00000032492
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pth1raENSDARG00000020957Danio rerio
 PTH1RENSGALG00000005476Gallus gallus
 PTH1RENSG00000160801Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pth2r / Q91V95 / Parathyroid hormone 2 receptor / P49190*ENSMUSG0000002594643
Vipr1 / P97751 / vasoactive intestinal peptide receptor 1 / P32241*ENSMUSG0000003252831
Sctr / Q5FWI2 / Secretin receptor / P47872*ENSMUSG0000002638730
Glp2r / Q5IXF8 / Glucagon-like peptide 2 receptor / O95838*ENSMUSG0000004992828
P70205 / Adcyap1r1 / adenylate cyclase activating polypeptide 1 receptor 1 / P41586* / ADCYAP receptor type I*ENSMUSG0000002977828
Vipr2 / P41588 / vasoactive intestinal peptide receptor 2 / P41587*ENSMUSG0000001117127
Glp1r / O35659 / Glucagon-like peptide 1 receptor / P43220*ENSMUSG0000002402727
Gipr / Q0P543 / Gastric inhibitory polypeptide receptor / P48546*ENSMUSG0000003040627
Gcgr / Q61606 / Glucagon receptor / P47871*ENSMUSG0000002512725
Ghrhr / P32082 / Growth hormone-releasing hormone receptor / Q02643*ENSMUSG0000000465424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR002170  GPCR, family 2, parathyroid hormone receptor
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001503 ossification IMP
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0002076 osteoblast development IMP
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0030282 bone mineralization IMP
 biological_processGO:0045453 bone resorption IMP
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004991 parathyroid hormone receptor activity TAS
 molecular_functionGO:0017046 peptide hormone binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043621 protein self-association ISO


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Ikbkaptm1.1Id/Ikbkaptm1.1Id
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * MF1

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * MF1

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ikbkaptm1.1Id/Ikbkaptm1.1Id
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pth1rtm1Hmk/Pth1rtm3Hmk,Tg(Col2a1-PTHR1*H223R)AHju/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pth1rtm2Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Ihhtm2Amc/Ihh+,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000167 reduced chondrocyte numbers "fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000168 abnormal bone marrow development "malformation or anomalous differentiation of the soft, pulpy tissue filling the medullary cavities of bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pthlhtm1Hmk/Pthlh+,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Aqp2tm1(AQP2)Suc/Aqp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000440 domed skull 
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * MF1

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * MF1

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * MF1

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * MF1

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0001565 abnormal circulating phosphate level "anomalous blood concentrations of this salt or ester of phosphoric acid; often associated with anomalous bone mineralization " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aqp2tm1(AQP2)Suc/Aqp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * MF1

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * MF1

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo6sv-2J/Myo6sv-2J
Genetic Background: B6.Cg-Myo6sv-2J/J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0002657 chondrodystrophy "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Col2a1-PTHLH)1Ecw/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * SJL

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0002905 decreased circulating parathyroid hormone level "less than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Aqp2tm1(AQP2)Suc/Aqp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pth1rtm2Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Pth1rtm3Hmk/Pth1rtm3Hmk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Col2a1-PTHLH)1Ecw/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0,Tg(Col2a1-PTHLH)1Ecw/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0003253 bile duct dilation "abnormal distention of the bile ducts due to accumulation of fluid or bile" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0004053 abnormal synchondrosis "anomalous or persistent cartilagenous fusion of two bones " [J:102870, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0004357 long tibia "increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0,Tg(Col2a1-PTHLH)1Ecw/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aqp2tm1(AQP2)Suc/Aqp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pthlhtm1Hmk/Pthlh+,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0006398 increased long bone epiphyseal plate size "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Ihhtm1Amc/Ihh+,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

 MP:0006429 abnormal hyaline cartilage morphology "any structural anomaly of the bluish-white, glassy, translucent nonvascular, resilient, flexible connective tissue; found primarily in articular cartilage, costal cartilages, the nasal septum, the larynx, and the trachea" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Col2a1-PTHLH)1Ecw/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * SJL

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aqp2tm1(AQP2)Suc/Aqp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009908 protruding tongue "the tongue extends out beyond the oral cavity past the lips; may be due to paralysis, oral cavity size, tongue hypoplasia or dysfunction of the hypoglossal nerve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0010200 enlarged lymphatic vessel "increased size of the network of vessels which carries lymph around the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0010490 abnormal inferior vena cava valve morphology "any structural anomaly of the semicircular fold of endocardium located on the right atrium at the point of attachment of the inferior vena cava" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0010912 herniated liver "protrusion of any portion of the liver from its normal anatomical position" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * MF1

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Shhtm1Amc/Shhtm1Amc
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0013774 decreased KLRG1-positive T-helper cell number "reduction in the number of CD4-positive alpha-beta T-helper cells expressing KLRG1, a marker associated with activation" [MGI:Saran]
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Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0013840 absent segment of posterior cerebral artery "absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0013846 retropharyngeal edema "accumulation of watery or serous fluid in the retropharyngeal space" [MGI:csmith]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0013864 enlarged paraumbilical vein "increased size of one or more of small superficial veins that run from the umbilicus along the round ligament of the liver and terminate as accessory portal veins in the liver" [ISBN:0-683-40008-8, PMID:7400038]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0013876 absent ductus venosus valve "absence of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0013877 abnormal ductus venosus valve morphology "any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0013963 jugular vein stenosis 
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0013971 blood in lymph vessels 
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0014000 anastomosis between internal carotid artery and basilar artery 
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0014001 abnormal vertebral artery topology "abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0014105 abnormal chondrocyte differentiation "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
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Allelic Composition: Ihhtm2Amc/Ihh+,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Ihhtm1Amc/Ihhtm2Amc,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Pth1rtm1Hmk/Pth1rtm2Hmk,Tg(Bglap2-cre)1Kry/0,Tg(Col2a1-PTHLH)1Ecw/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0014107 premature chondrocyte differentiation "early occurance of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0030094 foramen magnum stenosis "abnormal narrowing or constriction of the large orifice in the occipital bone through which the spinal cord passes to the cranial cavity and becomes continuous with the medulla oblongata" [MGI:anna]
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Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038300 Pth2 / Q91W27 / parathyroid hormone 2 / Q96A98*  / complex / reaction
 ENSMUSG00000048776 Pthlh / parathyroid hormone-like peptide / P12272* / parathyroid hormone like hormone*  / complex / reaction
 ENSMUSG00000059077 Pth / parathyroid hormone / P01270*  / reaction / complex






 

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