ENSDARG00000020957


Danio rerio

Features
Gene ID: ENSDARG00000020957
  
Biological name :pth1ra
  
Synonyms : parathyroid hormone 1 receptor a / pth1ra
  
Possible biological names infered from orthology : P41593 / parathyroid hormone 1 receptor / Parathyroid hormone/parathyroid hormone-related peptide receptor / PTH1R / Q03431
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 2290148
Gene end: 2451181
  
Corresponding Affymetrix probe sets: Dr.8130.1.S1_at (Zebrafish Array)   NM_131357_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000122146
Ensembl peptide - ENSDARP00000091807
NCBI entrez gene - 30629     See in Manteia.
RefSeq - NM_131357
RefSeq Peptide - NP_571432
swissprot - A2AVI7
swissprot - Q9PVD3
ZFIN ID - ZDB-GENE-991123-8
Ensembl - ENSDARG00000020957
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTH1RENSGALG00000005476Gallus gallus
 PTH1RENSG00000160801Homo sapiens
 Pth1rENSMUSG00000032492Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pth1rb / parathyroid hormone 1 receptor bENSDARG0000001841856
si:dkeyp-4h4.1 / PTH2R* / P49190* / Q91V95* / parathyroid hormone 2 receptor*ENSDARG0000002118652
pth2r / parathyroid hormone 2 receptor / P49190* / Q91V95*ENSDARG0000000667851
vipr1a / vasoactive intestinal peptide receptor 1a / VIPR1* / P32241* / P97751* / vasoactive intestinal peptide receptor 1*ENSDARG0000002887830
gipr / gastric inhibitory polypeptide receptor / P48546* / Q0P543*ENSDARG0000002547829
gcgra / glucagon receptor a / GCGR* / P47871* / glucagon receptor*ENSDARG0000010402229
gcgrb / glucagon receptor b / GCGR* / Q61606* / P47871* / glucagon receptor*ENSDARG0000003627229
vipr1b / vasoactive intestinal peptide receptor 1b / VIPR1* / P32241* / P97751* / vasoactive intestinal peptide receptor 1*ENSDARG0000005905829
adcyap1r1a / adcyap1r1b / adenylate cyclase activating polypeptide 1b (pituitary) receptor type I / P70205* / P41586* / ADCYAP1R1* / ADCYAP receptor type I* / adenylate cyclase activating p...ENSDARG0000005372428
vipr2 / vasoactive intestinal peptide receptor 2 / P41587* / P41588*ENSDARG0000001235328
ghrhr2 / growth hormone releasing hormone receptor 2 / GHRHR* / Q02643* / P32082* / growth hormone releasing hormone receptor*ENSDARG0000009921828
ghrhra / growth hormone releasing hormone receptor a / GHRHR* / Q02643* / P32082* / growth hormone releasing hormone receptor*ENSDARG0000010496127
ghrhrb / growth hormone releasing hormone receptor b / GHRHR* / Q02643* / P32082* / growth hormone releasing hormone receptor*ENSDARG0000005370826
SCTR / secretin receptor / P47872*ENSDARG0000010107723
adcyap1r1a / adenylate cyclase activating polypeptide 1a (pituitary) receptor type I / P70205* / P41586* / ADCYAP1R1* / ADCYAP receptor type I* / adenylate cyclase activating polypeptide 1 ...ENSDARG0000010520122


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR002170  GPCR, family 2, parathyroid hormone receptor
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0035907 dorsal aorta development IMP
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004991 parathyroid hormone receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IDA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta closed , abnormal
dorsal aorta endothelial cell aplastic , abnormal
Show

 ZFA:0000031 hypochord hypochord Notch signaling pathway decreased process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000031737 pthlha / parathyroid hormone-like hormone a / PTHLH* / P12272* / parathyroid hormone like hormone* / parathyroid hormone-like peptide*  / reaction / complex
 ENSDARG00000022951 pth2 / parathyroid hormone 2 / Q91W27* / Q96A98*  / reaction / complex
 ENSDARG00000071070 pthlhb / parathyroid hormone-like hormone b / PTHLH* / P12272* / parathyroid hormone like hormone* / parathyroid hormone-like peptide*  / complex / reaction






 

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