ENSGALG00000005476


Gallus gallus

Features
Gene ID: ENSGALG00000005476
  
Biological name :PTH1R
  
Synonyms : parathyroid hormone 1 receptor / PTH1R
  
Possible biological names infered from orthology : P41593 / Parathyroid hormone/parathyroid hormone-related peptide receptor / Q03431
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 3598940
Gene end: 3705027
  
Corresponding Affymetrix probe sets: GgaAffx.3437.2.S1_s_at (Chicken Array)   GgaAffx.3437.3.S1_at (Chicken Array)   GgaAffx.3437.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000008782
Ensembl peptide - ENSGALP00000047904
NCBI entrez gene - 420401     See in Manteia.
RefSeq - NM_001177575
RefSeq Peptide - NP_001171046
swissprot - C7S302
swissprot - A0A1D5P5D6
Ensembl - ENSGALG00000005476
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pth1raENSDARG00000020957Danio rerio
 PTH1RENSG00000160801Homo sapiens
 Pth1rENSMUSG00000032492Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000001979759
VIPR2 / vasoactive intestinal peptide receptor 2 / P41587* / P41588*ENSGALG0000000657531
SCTR / secretin receptor / P47872* / Q5FWI2*ENSGALG0000001210631
VIPR1 / vasoactive intestinal polypeptide receptor 1 precursor / P32241* / P97751* / vasoactive intestinal peptide receptor 1*ENSGALG0000000525931
ADCYAP1R1 / ADCYAP receptor type I / P41586* / P70205* / adenylate cyclase activating polypeptide 1 receptor 1*ENSGALG0000000522330
GLP2R / glucagon like peptide 2 receptor / O95838* / Q5IXF8*ENSGALG0000004180030
GHRHR / growth hormone releasing hormone receptor / P32082* / Q02643*ENSGALG0000000521229
ENSGALG0000000524228
growth hormone releasing hormone receptor precursor ENSGALG0000000027428
ENSGALG0000002889527
GCGR / glucagon receptor / P47871* / Q61606*ENSGALG0000001121927
GLP1R / glucagon like peptide 1 receptor / O35659* / P43220*ENSGALG0000001007827


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR002170  GPCR, family 2, parathyroid hormone receptor
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0002076 osteoblast development IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0048469 cell maturation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004991 parathyroid hormone receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043621 protein self-association IEA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000042878 PTH / P15743 / Parathyroid hormone / P01270*  / reaction / complex
 ENSGALG00000017295 PTHLH / P17251 / Parathyroid hormone-related protein Osteostatin / P12272* / parathyroid hormone like hormone* / parathyroid hormone-like peptide*  / reaction / complex






 

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