ENSMUSG00000049928


Mus musculus

Features
Gene ID: ENSMUSG00000049928
  
Biological name :Glp2r
  
Synonyms : Glp2r / Glucagon-like peptide 2 receptor / Q5IXF8
  
Possible biological names infered from orthology : O95838
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 67661502
Gene end: 67771153
  
Corresponding Affymetrix probe sets: 10387119 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000021289
Ensembl peptide - ENSMUSP00000061560
NCBI entrez gene - 93896     See in Manteia.
MGI - MGI:2136733
RefSeq - XM_006534562
RefSeq - NM_175681
RefSeq - XM_006534561
RefSeq Peptide - NP_783612
swissprot - Q5IXF8
swissprot - Q8BM22
swissprot - A0A158RFU9
Ensembl - ENSMUSG00000049928
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GLP2RENSGALG00000041800Gallus gallus
 GLP2RENSG00000065325Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gcgr / Q61606 / Glucagon receptor / P47871*ENSMUSG0000002512738
Glp1r / O35659 / Glucagon-like peptide 1 receptor / P43220*ENSMUSG0000002402738
Gipr / Q0P543 / Gastric inhibitory polypeptide receptor / P48546*ENSMUSG0000003040636
Pth1r / P41593 / Parathyroid hormone/parathyroid hormone-related peptide receptor / Q03431* / parathyroid hormone 1 receptor*ENSMUSG0000003249232
Vipr1 / P97751 / vasoactive intestinal peptide receptor 1 / P32241*ENSMUSG0000003252830
Sctr / Q5FWI2 / Secretin receptor / P47872*ENSMUSG0000002638730
Pth2r / Q91V95 / Parathyroid hormone 2 receptor / P49190*ENSMUSG0000002594629
P70205 / Adcyap1r1 / adenylate cyclase activating polypeptide 1 receptor 1 / P41586* / ADCYAP receptor type I*ENSMUSG0000002977828
Vipr2 / P41588 / vasoactive intestinal peptide receptor 2 / P41587*ENSMUSG0000001117128
Ghrhr / P32082 / Growth hormone-releasing hormone receptor / Q02643*ENSMUSG0000000465425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0071377 cellular response to glucagon stimulus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004967 glucagon receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2r+
Genetic Background: involves: C57BL/6J

Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2rtm1Ddr
Genetic Background: involves: C57BL/6J

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tg(Zp3-cre)93Knw/0,Zfp57tm1Xjli/Zfp57tm1Xjli
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * Black Swiss * C57BL/6J)

Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2rtm1Ddr
Genetic Background: involves: C57BL/6J

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2r+
Genetic Background: involves: C57BL/6J

Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2rtm1Ddr
Genetic Background: involves: C57BL/6J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2r+
Genetic Background: involves: C57BL/6J

Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2rtm1Ddr
Genetic Background: involves: C57BL/6J

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2r+
Genetic Background: involves: C57BL/6J

Allelic Composition: ApcMin/Apc+,Glp2rtm1Ddr/Glp2rtm1Ddr
Genetic Background: involves: C57BL/6J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

 MP:0011082 abnormal gastrointestinal motility "anomaly in the propulsive movements of the digestive system, resulting in the transit of the contents along the gastrointestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011945 increased eating frequency "increase in the number of discrete instances of initiation of eating over time, regardless of amount eaten" [MGI:csmith]
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0013487 abnormal Paneth cell physiology "any functional anomaly of the large secretory cells found at the base of the crypts of Lieberkuhn in the small intestine; Paneth cells contribute to the mucosal defense mechanism through the secretion of granules filled with antimicrobial (poly)peptides such as lysozyme, phospholipase A2, and defensins (called cryptdins in mice); Paneth cells secrete factors that help sustain and modulate the epithelial stem and progenitor cells that cohabitate in the crypts of Lieberkuhn and rejuvenate the small intestinal epithelium; dysfunction of Paneth cell biology contributes to the pathogenesis of chronic inflammatory bowel disease" [PMID:23398152]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000394 Gcg / P55095 / Glucagon Glicentin Glicentin-related polypeptide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like pepti...  / reaction / complex






 

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