ENSMUSG00000030406


Mus musculus

Features
Gene ID: ENSMUSG00000030406
  
Biological name :Gipr
  
Synonyms : Gastric inhibitory polypeptide receptor / Gipr / Q0P543
  
Possible biological names infered from orthology : P48546
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 19156061
Gene end: 19166127
  
Corresponding Affymetrix probe sets: 10560443 (MoGene1.0st)   1445790_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092384
Ensembl peptide - ENSMUSP00000145860
NCBI entrez gene - 381853     See in Manteia.
MGI - MGI:1352753
RefSeq - XM_011250615
RefSeq - NM_001080815
RefSeq - XM_006540144
RefSeq - XM_006540145
RefSeq - XM_006540147
RefSeq - XM_006540142
RefSeq - XM_006540143
RefSeq Peptide - NP_001074284
swissprot - Q0P543
swissprot - A0A0U1RP73
Ensembl - ENSMUSG00000030406
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 giprENSDARG00000025478Danio rerio
 GIPRENSG00000010310Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gcgr / Q61606 / Glucagon receptor / P47871*ENSMUSG0000002512748
Glp1r / O35659 / Glucagon-like peptide 1 receptor / P43220*ENSMUSG0000002402742
Glp2r / Q5IXF8 / Glucagon-like peptide 2 receptor / O95838*ENSMUSG0000004992840
Sctr / Q5FWI2 / Secretin receptor / P47872*ENSMUSG0000002638736
Vipr1 / P97751 / vasoactive intestinal peptide receptor 1 / P32241*ENSMUSG0000003252835
Pth1r / P41593 / Parathyroid hormone/parathyroid hormone-related peptide receptor / Q03431* / parathyroid hormone 1 receptor*ENSMUSG0000003249235
P70205 / Adcyap1r1 / adenylate cyclase activating polypeptide 1 receptor 1 / P41586* / ADCYAP receptor type I*ENSMUSG0000002977832
Vipr2 / P41588 / vasoactive intestinal peptide receptor 2 / P41587*ENSMUSG0000001117132
Pth2r / Q91V95 / Parathyroid hormone 2 receptor / P49190*ENSMUSG0000002594630
Ghrhr / P32082 / Growth hormone-releasing hormone receptor / Q02643*ENSMUSG0000000465428


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001749  GPCR, family 2, gastric inhibitory polypeptide receptor
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002029 desensitization of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007218 neuropeptide signaling pathway TAS
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0038192 gastric inhibitory peptide signaling pathway IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0070542 response to fatty acid IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016519 gastric inhibitory peptide receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002694 abnormal pancreas secretion "altered ability of the pancreas to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitW-19H/Kit+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Giprtm1Thor/Giprtm1Thor,Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Giprtm1Thor/Giprtm1Thor
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Giprtm1Thor/Giprtm1Thor,Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Giprtm1Thor/Giprtm1Thor
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Giprtm1Thor/Giprtm1Thor,Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Giprtm1Thor/Giprtm1Thor
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Giprtm1Thor/Giprtm1Thor,Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014351 Gip / P48756 / Gastric inhibitory polypeptide / P09681*  / reaction / complex






 

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