ENSMUSG00000029778


Mus musculus

Features
Gene ID: ENSMUSG00000029778
  
Biological name :Adcyap1r1
  
Synonyms : Adcyap1r1 / adenylate cyclase activating polypeptide 1 receptor 1 / P70205
  
Possible biological names infered from orthology : ADCYAP receptor type I / P41586
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B3
Gene start: 55451978
Gene end: 55501451
  
Corresponding Affymetrix probe sets: 10538482 (MoGene1.0st)   1429022_at (Mouse Genome 430 2.0 Array)   1439042_at (Mouse Genome 430 2.0 Array)   1450799_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126994
Ensembl peptide - ENSMUSP00000131641
Ensembl peptide - ENSMUSP00000130923
Ensembl peptide - ENSMUSP00000130742
Ensembl peptide - ENSMUSP00000129614
Ensembl peptide - ENSMUSP00000127319
Ensembl peptide - ENSMUSP00000063784
Ensembl peptide - ENSMUSP00000066902
NCBI entrez gene - 11517     See in Manteia.
MGI - MGI:108449
RefSeq - XM_011241153
RefSeq - XM_011241152
RefSeq - XM_011241151
RefSeq - XM_011241150
RefSeq - NM_001025372
RefSeq - XM_006505388
RefSeq - NM_007407
RefSeq Peptide - NP_001020543
RefSeq Peptide - NP_031433
swissprot - P70205
swissprot - Q6NXJ9
swissprot - E9QAL0
swissprot - E9PVE8
swissprot - E9Q3E8
swissprot - E9Q4B3
swissprot - E9Q968
Ensembl - ENSMUSG00000029778
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcyap1r1aENSDARG00000105201Danio rerio
 adcyap1r1aENSDARG00000053724Danio rerio
 ADCYAP1R1ENSGALG00000005223Gallus gallus
 P41586ENSG00000078549Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vipr1 / P97751 / vasoactive intestinal peptide receptor 1 / P32241*ENSMUSG0000003252845
Vipr2 / P41588 / vasoactive intestinal peptide receptor 2 / P41587*ENSMUSG0000001117142
Sctr / Q5FWI2 / Secretin receptor / P47872*ENSMUSG0000002638740
Ghrhr / P32082 / Growth hormone-releasing hormone receptor / Q02643*ENSMUSG0000000465434
Pth1r / P41593 / Parathyroid hormone/parathyroid hormone-related peptide receptor / Q03431* / parathyroid hormone 1 receptor*ENSMUSG0000003249233
Gcgr / Q61606 / Glucagon receptor / P47871*ENSMUSG0000002512732
Glp1r / O35659 / Glucagon-like peptide 1 receptor / P43220*ENSMUSG0000002402730
Glp2r / Q5IXF8 / Glucagon-like peptide 2 receptor / O95838*ENSMUSG0000004992829
Pth2r / Q91V95 / Parathyroid hormone 2 receptor / P49190*ENSMUSG0000002594629
Gipr / Q0P543 / Gastric inhibitory polypeptide receptor / P48546*ENSMUSG0000003040629


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR002285  GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033555 multicellular organismal response to stress IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046545 development of primary female sexual characteristics IEA
 biological_processGO:0051057 positive regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004999 vasoactive intestinal polypeptide receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008179 adenylate cyclase binding IEA
 molecular_functionGO:0030306 ADP-ribosylation factor binding IEA
 molecular_functionGO:0042923 neuropeptide binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Adcyap1r1tm1.2Gsc/Adcyap1r1tm1.2Gsc,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Adcyap1tm1Nms/Adcyap1tm1Nms
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

 MP:0020475 delayed circadian behavior phase "decrease in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024256 O70176 / Adcyap1 / adenylate cyclase activating polypeptide 1 / P18509*  / complex / reaction






 

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