ENSMUSG00000026387


Mus musculus

Features
Gene ID: ENSMUSG00000026387
  
Biological name :Sctr
  
Synonyms : Q5FWI2 / Sctr / Secretin receptor
  
Possible biological names infered from orthology : P47872
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E2.3
Gene start: 120006894
Gene end: 120063536
  
Corresponding Affymetrix probe sets: 10349319 (MoGene1.0st)   1443454_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072660
Ensembl peptide - ENSMUSP00000139932
NCBI entrez gene - 319229     See in Manteia.
MGI - MGI:2441720
RefSeq - XM_011248031
RefSeq - NM_001012322
RefSeq - NM_001311077
RefSeq - XM_006529686
RefSeq - XM_006529688
RefSeq - XM_011248029
RefSeq - XM_011248030
RefSeq - XM_006529683
RefSeq - XM_006529684
RefSeq - XM_006529685
RefSeq Peptide - NP_001012322
RefSeq Peptide - NP_001298006
swissprot - Q5FWI2
swissprot - H7BX37
Ensembl - ENSMUSG00000026387
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SCTRENSDARG00000101077Danio rerio
 SCTRENSGALG00000012106Gallus gallus
 SCTRENSG00000080293Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vipr1 / P97751 / vasoactive intestinal peptide receptor 1 / P32241*ENSMUSG0000003252843
P70205 / Adcyap1r1 / adenylate cyclase activating polypeptide 1 receptor 1 / P41586* / ADCYAP receptor type I*ENSMUSG0000002977843
Vipr2 / P41588 / vasoactive intestinal peptide receptor 2 / P41587*ENSMUSG0000001117142
Pth1r / P41593 / Parathyroid hormone/parathyroid hormone-related peptide receptor / Q03431* / parathyroid hormone 1 receptor*ENSMUSG0000003249238
Glp1r / O35659 / Glucagon-like peptide 1 receptor / P43220*ENSMUSG0000002402736
Gipr / Q0P543 / Gastric inhibitory polypeptide receptor / P48546*ENSMUSG0000003040635
Ghrhr / P32082 / Growth hormone-releasing hormone receptor / Q02643*ENSMUSG0000000465435
Gcgr / Q61606 / Glucagon receptor / P47871*ENSMUSG0000002512735
Glp2r / Q5IXF8 / Glucagon-like peptide 2 receptor / O95838*ENSMUSG0000004992833
Pth2r / Q91V95 / Parathyroid hormone 2 receptor / P49190*ENSMUSG0000002594633


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR002144  GPCR, family 2, secretin receptor
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0005881 cytoplasmic microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0015055 secretin receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0001422 abnormal drinking behavior "an altered pattern of fluid consumption or altered preference for particular fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003014 abnormal kidney medulla morphology "anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005609 abnormal circulating antidiuretic hormone level "deviation from the normal concentration of this peptide hormone in the blood; it is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011467 decreased urine urea nitrogen level "abnormally low amounts of nitrogen in the form of urea in the urine" [MGI:csmith]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011501 increased glomerular capsule space "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]
Show

Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0020338 abnormal hippocampal pyramidal neuron dendrite morphology "structural anomaly of the highly branched tree-like process of the hippocampal neurons that have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base" [CL_1001571, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

 MP:0020396 abnormal social recognition "any anomaly in the ability of an individual to recognize another individual of the same species during repeated encounters" [PMID:11950245]
Show

Allelic Composition: Fgf4tm1Gol/Fgf4tm1Gol
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038580 Sct / Q08535 / secretin / P09683*  / reaction / complex






 

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