ENSMUSG00000038580


Mus musculus

Features
Gene ID: ENSMUSG00000038580
  
Biological name :Sct
  
Synonyms : Q08535 / Sct / secretin
  
Possible biological names infered from orthology : P09683
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 141278330
Gene end: 141279133
  
Corresponding Affymetrix probe sets: 10569129 (MoGene1.0st)   1418805_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041519
Ensembl peptide - ENSMUSP00000128729
Ensembl peptide - ENSMUSP00000147780
NCBI entrez gene - 20287     See in Manteia.
MGI - MGI:99466
RefSeq - XM_017322065
RefSeq - NM_001287171
RefSeq - NM_001309439
RefSeq - NM_011328
RefSeq Peptide - NP_001274100
RefSeq Peptide - NP_001296368
RefSeq Peptide - NP_035458
swissprot - Q08535
swissprot - Q3UKU8
swissprot - Q80ZS9
swissprot - A0A1B0GS37
Ensembl - ENSMUSG00000038580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SCTENSG00000070031Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000532  Glucagon/GIP/secretin/VIP
 IPR015675  Secretin precursor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021542 dentate gyrus development IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0048566 embryonic digestive tract development IEA
 biological_processGO:0090187 positive regulation of pancreatic juice secretion IEA
 biological_processGO:0090274 positive regulation of somatostatin secretion IEA
 biological_processGO:0097150 neuronal stem cell population maintenance IMP
 biological_processGO:1903640 negative regulation of gastrin-induced gastric acid secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001422 abnormal drinking behavior "an altered pattern of fluid consumption or altered preference for particular fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: involves: 129S6/SvEvTac

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Hif1atm1Stom/Hif1atm1Stom,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB/N

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hif1atm1Stom/Hif1atm1Stom,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB/N

 MP:0002922 decreased post-tetanic potential "reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hif1atm1Stom/Hif1atm1Stom,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB/N

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: involves: 129S6/SvEvTac

 MP:0005609 abnormal circulating antidiuretic hormone level "deviation from the normal concentration of this peptide hormone in the blood; it is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026387 Sctr / Q5FWI2 / Secretin receptor / P47872*  / reaction / complex






 

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