ENSMUSG00000011171


Mus musculus

Features
Gene ID: ENSMUSG00000011171
  
Biological name :Vipr2
  
Synonyms : P41588 / vasoactive intestinal peptide receptor 2 / Vipr2
  
Possible biological names infered from orthology : P41587
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F2
Gene start: 116077726
Gene end: 116146261
  
Corresponding Affymetrix probe sets: 10399046 (MoGene1.0st)   1421391_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000011315
Ensembl peptide - ENSMUSP00000135149
NCBI entrez gene - 22355     See in Manteia.
MGI - MGI:107166
RefSeq - XM_017315043
RefSeq - NM_009511
RefSeq - XM_006515805
RefSeq - XM_006515806
RefSeq - XM_011244102
RefSeq Peptide - NP_033537
swissprot - H3BJW2
swissprot - P41588
swissprot - Q546Q8
Ensembl - ENSMUSG00000011171
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vipr2ENSDARG00000012353Danio rerio
 VIPR2ENSGALG00000006575Gallus gallus
 VIPR2ENSG00000106018Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vipr1 / P97751 / vasoactive intestinal peptide receptor 1 / P32241*ENSMUSG0000003252849
P70205 / Adcyap1r1 / adenylate cyclase activating polypeptide 1 receptor 1 / P41586* / ADCYAP receptor type I*ENSMUSG0000002977847
Sctr / Q5FWI2 / Secretin receptor / P47872*ENSMUSG0000002638744
Pth1r / P41593 / Parathyroid hormone/parathyroid hormone-related peptide receptor / Q03431* / parathyroid hormone 1 receptor*ENSMUSG0000003249237
Pth2r / Q91V95 / Parathyroid hormone 2 receptor / P49190*ENSMUSG0000002594635
Ghrhr / P32082 / Growth hormone-releasing hormone receptor / Q02643*ENSMUSG0000000465435
Gcgr / Q61606 / Glucagon receptor / P47871*ENSMUSG0000002512734
Glp1r / O35659 / Glucagon-like peptide 1 receptor / P43220*ENSMUSG0000002402734
Gipr / Q0P543 / Gastric inhibitory polypeptide receptor / P48546*ENSMUSG0000003040634
Glp2r / Q5IXF8 / Glucagon-like peptide 2 receptor / O95838*ENSMUSG0000004992833


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001571  GPCR, family 2, vasoactive intestinal peptide receptor
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR002284  GPCR, family 2, vasoactive intestinal peptide receptor 2
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007190 activation of adenylate cyclase activity IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004999 vasoactive intestinal polypeptide receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005480 increased circulating triiodothyronine level "greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

Allelic Composition: Vipr2tm1Ajh/Vipr2tm1Ajh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0020471 abnormal circadian behavior persistence "anomaly in the ability for an animal to retain a circadian behavior when time cues are removed" [MGI:smb]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0020472 arrhythmic circadian behavior persistence "loss of a behavioral rhythmic pattern upon removal of time cues" [MGI:smb]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

Allelic Composition: Vipr2tm1Ajh/Vipr2tm1Ajh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

Allelic Composition: Vipr2tm1Ajh/Vipr2tm1Ajh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019772 Vip / vasoactive intestinal polypeptide / P01282* / vasoactive intestinal peptide*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr