ENSG00000112164


Homo sapiens

Features
Gene ID: ENSG00000112164
  
Biological name :GLP1R
  
Synonyms : GLP1R / glucagon like peptide 1 receptor / P43220
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.2
Gene start: 39048798
Gene end: 39087743
  
Corresponding Affymetrix probe sets: 208390_s_at (Human Genome U133 Plus 2.0 Array)   208391_s_at (Human Genome U133 Plus 2.0 Array)   208400_at (Human Genome U133 Plus 2.0 Array)   208401_s_at (Human Genome U133 Plus 2.0 Array)   211232_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362353
NCBI entrez gene - 2740     See in Manteia.
OMIM - 138032
RefSeq - NM_002062
RefSeq - XM_017010750
RefSeq Peptide - NP_002053
swissprot - P43220
Ensembl - ENSG00000112164
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GLP1RENSGALG00000010078Gallus gallus
 Glp1rENSMUSG00000024027Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GCGR / P47871 / glucagon receptorENSG0000021564446
GLP2R / O95838 / glucagon like peptide 2 receptorENSG0000006532542
GIPR / P48546 / gastric inhibitory polypeptide receptorENSG0000001031042
VIPR1 / P32241 / vasoactive intestinal peptide receptor 1ENSG0000011481236
SCTR / P47872 / secretin receptorENSG0000008029336
PTH1R / Q03431 / parathyroid hormone 1 receptorENSG0000016080134
VIPR2 / P41587 / vasoactive intestinal peptide receptor 2ENSG0000010601832
P41586 / ADCYAP1R1 / ADCYAP receptor type IENSG0000007854931
PTH2R / P49190 / parathyroid hormone 2 receptorENSG0000014440731
GHRHR / Q02643 / growth hormone releasing hormone receptorENSG0000010612831


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003290  GPCR, family 2, glucagon-like peptide-1/glucagon receptor
 IPR003292  GPCR, family 2, glucagon-like peptide-1 receptor
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0008016 regulation of heart contraction IEA
 biological_processGO:0019933 cAMP-mediated signaling IDA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0071377 cellular response to glucagon stimulus IEA
 biological_processGO:1990911 response to psychosocial stress IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004967 glucagon receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IEA
 molecular_functionGO:0044508 glucagon-like peptide 1 receptor activity IDA


Pathways (from Reactome)
Pathway description
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087460 GNAS / O95467 / Q5JWF2 / P63092 / P84996 / GNAS complex locus  / complex
 ENSG00000115263 GCG / P01275 / glucagon  / reaction / complex






 

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