ENSG00000144407


Homo sapiens

Features
Gene ID: ENSG00000144407
  
Biological name :PTH2R
  
Synonyms : P49190 / parathyroid hormone 2 receptor / PTH2R
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q34
Gene start: 208359714
Gene end: 208854503
  
Corresponding Affymetrix probe sets: 206772_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482485
Ensembl peptide - ENSP00000272847
Ensembl peptide - ENSP00000393930
NCBI entrez gene - 5746     See in Manteia.
OMIM - 601469
RefSeq - NM_005048
RefSeq - NM_001309516
RefSeq Peptide - NP_001296445
RefSeq Peptide - NP_005039
swissprot - P49190
swissprot - B4DFN8
swissprot - H7C0B0
Ensembl - ENSG00000144407
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pth2rENSDARG00000006678Danio rerio
 si:dkeyp-4h4.1ENSDARG00000021186Danio rerio
 Pth2rENSMUSG00000025946Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTH1R / Q03431 / parathyroid hormone 1 receptorENSG0000016080149
SCTR / P47872 / secretin receptorENSG0000008029330
VIPR1 / P32241 / vasoactive intestinal peptide receptor 1ENSG0000011481228
GLP2R / O95838 / glucagon like peptide 2 receptorENSG0000006532527
VIPR2 / P41587 / vasoactive intestinal peptide receptor 2ENSG0000010601826
GLP1R / P43220 / glucagon like peptide 1 receptorENSG0000011216426
GCGR / P47871 / glucagon receptorENSG0000021564426
GIPR / P48546 / gastric inhibitory polypeptide receptorENSG0000001031025
GHRHR / Q02643 / growth hormone releasing hormone receptorENSG0000010612825
P41586 / ADCYAP1R1 / ADCYAP receptor type IENSG0000007854925


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004991 parathyroid hormone receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087494 PTHLH / P12272 / parathyroid hormone like hormone  / reaction / complex
 ENSG00000142538 PTH2 / Q96A98 / parathyroid hormone 2  / complex / reaction
 ENSG00000152266 PTH / P01270 / parathyroid hormone  / reaction / complex






 

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