ENSG00000078098


Homo sapiens

Features
Gene ID: ENSG00000078098
  
Biological name :FAP
  
Synonyms : FAP / fibroblast activation protein alpha / Q12884
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q24.2
Gene start: 162170684
Gene end: 162245151
  
Corresponding Affymetrix probe sets: 209955_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407404
Ensembl peptide - ENSP00000485844
Ensembl peptide - ENSP00000441940
Ensembl peptide - ENSP00000417028
Ensembl peptide - ENSP00000411391
Ensembl peptide - ENSP00000188790
Ensembl peptide - ENSP00000400137
NCBI entrez gene - 2191     See in Manteia.
OMIM - 600403
RefSeq - XM_011510797
RefSeq - NM_001291807
RefSeq - NM_004460
RefSeq - XM_011510796
RefSeq Peptide - NP_004451
RefSeq Peptide - NP_001278736
swissprot - Q12884
swissprot - C9J131
swissprot - A0A0D9SEN1
swissprot - B4DLR2
swissprot - H0YG61
swissprot - F8WF29
swissprot - H7C4D9
Ensembl - ENSG00000078098
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dpp4ENSDARG00000079420Danio rerio
 fapENSDARG00000078468Danio rerio
 FAPENSGALG00000011099Gallus gallus
 FapENSMUSG00000000392Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DPP4 / P27487 / dipeptidyl peptidase 4ENSG0000019763551
DPP10 / Q8N608 / dipeptidyl peptidase like 10ENSG0000017549733
DPP6 / P42658 / dipeptidyl peptidase like 6ENSG0000013022631
DPP8 / Q6V1X1 / dipeptidyl peptidase 8ENSG0000007460322
DPP9 / Q86TI2 / dipeptidyl peptidase 9ENSG0000014200221


Protein motifs (from Interpro)
Interpro ID Name
 IPR001375  Peptidase S9, prolyl oligopeptidase, catalytic domain
 IPR002469  Dipeptidylpeptidase IV, N-terminal domain
 IPR002471  Peptidase S9, serine active site
 IPR029058  Alpha/Beta hydrolase fold
 IPR031245  Dipeptidyl peptidase FAP


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010710 regulation of collagen catabolic process IDA
 biological_processGO:0010716 negative regulation of extracellular matrix disassembly IDA
 biological_processGO:0043542 endothelial cell migration IDA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IDA
 biological_processGO:0051917 regulation of fibrinolysis IC
 biological_processGO:0060244 negative regulation of cell proliferation involved in contact inhibition IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0071850 mitotic cell cycle arrest IEA
 biological_processGO:0097325 melanocyte proliferation IEA
 biological_processGO:1900119 positive regulation of execution phase of apoptosis IEA
 biological_processGO:1902362 melanocyte apoptotic process IEA
 biological_processGO:1903054 negative regulation of extracellular matrix organization IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane NAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0032587 ruffle membrane NAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0045178 basal part of cell IEA
 cellular_componentGO:0071438 invadopodium membrane IEA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004222 metalloendopeptidase activity TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0008239 dipeptidyl-peptidase activity NAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity NAS
 molecular_functionGO:0046983 protein dimerization activity NAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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