ENSMUSG00000000392


Mus musculus

Features
Gene ID: ENSMUSG00000000392
  
Biological name :Fap
  
Synonyms : Fap / P97321 / Prolyl endopeptidase FAP Antiplasmin-cleaving enzyme FAP, soluble form
  
Possible biological names infered from orthology : fibroblast activation protein alpha / Q12884
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.3
Gene start: 62500943
Gene end: 62574075
  
Corresponding Affymetrix probe sets: 10483081 (MoGene1.0st)   1417552_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134386
Ensembl peptide - ENSMUSP00000000402
Ensembl peptide - ENSMUSP00000099793
Ensembl peptide - ENSMUSP00000133792
Ensembl peptide - ENSMUSP00000134074
Ensembl peptide - ENSMUSP00000134305
NCBI entrez gene - 14089     See in Manteia.
MGI - MGI:109608
RefSeq - XM_017315512
RefSeq - NM_007986
RefSeq - XM_006498746
RefSeq - XM_011239289
RefSeq - XM_017315507
RefSeq Peptide - NP_032012
swissprot - P97321
swissprot - G3UZ14
swissprot - G3UYG3
swissprot - G3UXR2
Ensembl - ENSMUSG00000000392
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dpp4ENSDARG00000079420Danio rerio
 fapENSDARG00000078468Danio rerio
 FAPENSGALG00000011099Gallus gallus
 FAPENSG00000078098Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dpp4 / P28843 / Dipeptidyl peptidase 4 Dipeptidyl peptidase 4 membrane form Dipeptidyl peptidase 4 soluble form / P27487* / dipeptidyl peptidase 4*ENSMUSG0000003500052
Dpp10 / dipeptidyl peptidase like 10 / Q8N608*ENSMUSG0000003681532
Dpp6 / Q9Z218 / Dipeptidyl aminopeptidase-like protein 6 / P42658* / dipeptidyl peptidase like 6*ENSMUSG0000006157630
Dpp8 / Q80YA7 / Dipeptidyl peptidase 8 / Q6V1X1*ENSMUSG0000003239322
Dpp9 / Q8BVG4 / Dipeptidyl peptidase 9 / Q86TI2*ENSMUSG0000000122921


Protein motifs (from Interpro)
Interpro ID Name
 IPR001375  Peptidase S9, prolyl oligopeptidase, catalytic domain
 IPR002469  Dipeptidylpeptidase IV, N-terminal domain
 IPR002471  Peptidase S9, serine active site
 IPR029058  Alpha/Beta hydrolase fold
 IPR031245  Dipeptidyl peptidase FAP


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010710 regulation of collagen catabolic process ISO
 biological_processGO:0010716 negative regulation of extracellular matrix disassembly ISO
 biological_processGO:0043542 endothelial cell migration ISS
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process ISS
 biological_processGO:0060244 negative regulation of cell proliferation involved in contact inhibition IDA
 biological_processGO:0071158 positive regulation of cell cycle arrest IDA
 biological_processGO:0071850 mitotic cell cycle arrest IDA
 biological_processGO:0097325 melanocyte proliferation IDA
 biological_processGO:1900119 positive regulation of execution phase of apoptosis IDA
 biological_processGO:1902362 melanocyte apoptotic process IDA
 biological_processGO:1903054 negative regulation of extracellular matrix organization ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0045178 basal part of cell IDA
 cellular_componentGO:0071438 invadopodium membrane ISO
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0004175 endopeptidase activity ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity ISO
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity ISO
 molecular_functionGO:0008239 dipeptidyl-peptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Faptm1Schn/Faptm1Schn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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