ENSMUSG00000061576


Mus musculus

Features
Gene ID: ENSMUSG00000061576
  
Biological name :Dpp6
  
Synonyms : Dipeptidyl aminopeptidase-like protein 6 / Dpp6 / Q9Z218
  
Possible biological names infered from orthology : dipeptidyl peptidase like 6 / P42658
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 26817203
Gene end: 27727505
  
Corresponding Affymetrix probe sets: 10520318 (MoGene1.0st)   10520351 (MoGene1.0st)   1439748_at (Mouse Genome 430 2.0 Array)   1451394_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071435
Ensembl peptide - ENSMUSP00000113441
Ensembl peptide - ENSMUSP00000113849
Ensembl peptide - ENSMUSP00000115944
Ensembl peptide - ENSMUSP00000099012
NCBI entrez gene - 13483     See in Manteia.
MGI - MGI:94921
RefSeq - NM_001198886
RefSeq - NM_001136060
RefSeq - NM_010075
RefSeq - NM_207282
RefSeq Peptide - NP_997165
RefSeq Peptide - NP_001129532
RefSeq Peptide - NP_001185815
RefSeq Peptide - NP_034205
swissprot - Q80VM5
swissprot - D6RFR3
swissprot - Q9Z218
swissprot - E9PWX1
swissprot - Q5U4C2
Ensembl - ENSMUSG00000061576
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dpp6aENSDARG00000076826Danio rerio
 dpp6bENSDARG00000024744Danio rerio
 DPP6ENSGALG00000041791Gallus gallus
 DPP6ENSG00000130226Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dpp10 / dipeptidyl peptidase like 10 / Q8N608*ENSMUSG0000003681546
Dpp4 / P28843 / Dipeptidyl peptidase 4 Dipeptidyl peptidase 4 membrane form Dipeptidyl peptidase 4 soluble form / P27487* / dipeptidyl peptidase 4*ENSMUSG0000003500027
Fap / P97321 / Prolyl endopeptidase FAP Antiplasmin-cleaving enzyme FAP, soluble form / Q12884* / fibroblast activation protein alpha*ENSMUSG0000000039227
Dpp8 / Q80YA7 / Dipeptidyl peptidase 8 / Q6V1X1*ENSMUSG0000003239320
Dpp9 / Q8BVG4 / Dipeptidyl peptidase 9 / Q86TI2*ENSMUSG0000000122920


Protein motifs (from Interpro)
Interpro ID Name
 IPR001375  Peptidase S9, prolyl oligopeptidase, catalytic domain
 IPR002469  Dipeptidylpeptidase IV, N-terminal domain
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0019228 neuronal action potential IMP
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0043266 regulation of potassium ion transport IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:1901379 regulation of potassium ion transmembrane transport IEA
 biological_processGO:1901381 positive regulation of potassium ion transmembrane transport IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0015459 potassium channel regulator activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdpd5tm1.1Itl/Gdpd5tm1.1Itl,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * CBA

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
Show

Allelic Composition: Gdpd5tm1.1Itl/Gdpd5tm1.1Itl,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * CBA

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Gdpd5tm1.1Itl/Gdpd5tm1.1Itl,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * CBA

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gdpd5tm1.1Itl/Gdpd5tm1.1Itl,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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