ENSGALG00000042452


Gallus gallus

Features
Gene ID: ENSGALG00000042452
  
Biological name :DPP4
  
Synonyms : dipeptidyl peptidase 4 / DPP4
  
Possible biological names infered from orthology : Dipeptidyl peptidase 4 Dipeptidyl peptidase 4 membrane form Dipeptidyl peptidase 4 soluble form / P27487 / P28843
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 21251160
Gene end: 21289953
  
Corresponding Affymetrix probe sets: Gga.8886.1.S1_at (Chicken Array)   Gga.8886.2.S1_at (Chicken Array)   GgaAffx.13006.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000060682
Ensembl peptide - ENSGALP00000052897
NCBI entrez gene - 424187     See in Manteia.
RefSeq - XM_015289645
RefSeq - NM_001031255
RefSeq Peptide - NP_001026426
swissprot - Q5ZI81
swissprot - A0A1D5PJA5
Ensembl - ENSGALG00000042452
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dpp4ENSDARG00000079420Danio rerio
 fapENSDARG00000078468Danio rerio
 DPP4ENSG00000197635Homo sapiens
 Dpp4ENSMUSG00000035000Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FAP / prolyl endopeptidase FAP / P97321* / Q12884* / fibroblast activation protein alpha* / Prolyl endopeptidase FAP Antiplasmin-cleaving enzyme FAP, soluble form*ENSGALG0000001109956
DPP10 / dipeptidyl peptidase like 10 / Q8N608*ENSGALG0000001215634
DPP6 / dipeptidyl peptidase like 6 / P42658* / Q9Z218* / Dipeptidyl aminopeptidase-like protein 6 *ENSGALG0000004179131
DPP8 / dipeptidyl peptidase 8 / Q6V1X1* / Q80YA7*ENSGALG0000000743723
DPP9 / dipeptidyl peptidase 9 / Q86TI2* / Q8BVG4*ENSGALG0000000420022


Protein motifs (from Interpro)
Interpro ID Name
 IPR001375  Peptidase S9, prolyl oligopeptidase, catalytic domain
 IPR002469  Dipeptidylpeptidase IV, N-terminal domain
 IPR002471  Peptidase S9, serine active site
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010716 negative regulation of extracellular matrix disassembly IEA
 biological_processGO:0031295 T cell costimulation IEA
 biological_processGO:0033632 regulation of cell-cell adhesion mediated by integrin IEA
 biological_processGO:0035641 locomotory exploration behavior IEA
 biological_processGO:0036343 psychomotor behavior IEA
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0043542 endothelial cell migration IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0046581 intercellular canaliculus IEA
 cellular_componentGO:0071438 invadopodium membrane IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0008239 dipeptidyl-peptidase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011104 GCG / P68259 / Glucagon Glicentin-related polypeptide Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like peptide 2 / P01275* / P55095...  / reaction






 

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