ENSMUSG00000027523


Mus musculus

Features
Gene ID: ENSMUSG00000027523
  
Biological name :Gnas
  
Synonyms : Gnas / GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus / P63094 / Q6R0H6 / Q6R0H7 / Q9Z0F1
  
Possible biological names infered from orthology : GNAS complex locus / O95467 / P63092 / P84996 / Q5JWF2
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H4
Gene start: 174284320
Gene end: 174346744
  
Corresponding Affymetrix probe sets: 10479112 (MoGene1.0st)   1421740_at (Mouse Genome 430 2.0 Array)   1427789_s_at (Mouse Genome 430 2.0 Array)   1443375_at (Mouse Genome 430 2.0 Array)   1450186_s_at (Mouse Genome 430 2.0 Array)   1453413_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136180
Ensembl peptide - ENSMUSP00000122230
Ensembl peptide - ENSMUSP00000139839
Ensembl peptide - ENSMUSP00000140174
Ensembl peptide - ENSMUSP00000079341
Ensembl peptide - ENSMUSP00000085179
Ensembl peptide - ENSMUSP00000085184
Ensembl peptide - ENSMUSP00000085185
Ensembl peptide - ENSMUSP00000104711
Ensembl peptide - ENSMUSP00000104712
Ensembl peptide - ENSMUSP00000104713
Ensembl peptide - ENSMUSP00000104715
Ensembl peptide - ENSMUSP00000104716
Ensembl peptide - ENSMUSP00000104723
Ensembl peptide - ENSMUSP00000104724
Ensembl peptide - ENSMUSP00000118210
NCBI entrez gene - 14683     See in Manteia.
MGI - MGI:95777
RefSeq - NM_019690
RefSeq - NM_001077507
RefSeq - NM_001077510
RefSeq - NM_001310083
RefSeq - NM_001310085
RefSeq - NM_010309
RefSeq - NM_022000
RefSeq - NM_201616
RefSeq - NM_201617
RefSeq - NM_201618
RefSeq - XM_006498774
RefSeq - XM_006498776
RefSeq - XM_006498777
RefSeq - XM_006498778
RefSeq - XM_006498779
RefSeq - XM_006498780
RefSeq - XM_017315658
RefSeq Peptide - NP_034439
RefSeq Peptide - NP_062664
RefSeq Peptide - NP_068840
RefSeq Peptide - NP_963910
RefSeq Peptide - NP_963911
RefSeq Peptide - NP_963912
RefSeq Peptide - NP_001070975
RefSeq Peptide - NP_001070978
RefSeq Peptide - NP_001297012
RefSeq Peptide - NP_001297014
swissprot - A6PW71
swissprot - A6PW70
swissprot - Q6R0H6
swissprot - Q6R0H7
swissprot - Q9Z0F1
swissprot - Z4YKV1
swissprot - P63094
swissprot - A2A610
Ensembl - ENSMUSG00000027523
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNASENSG00000087460Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gnal / Q8CGK7 / guanine nucleotide binding protein, alpha stimulating, olfactory type / P38405* / G protein subunit alpha L*ENSMUSG0000002452426


Protein motifs (from Interpro)
Interpro ID Name
 IPR000367  G-protein alpha subunit, group S
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR009434  Neuroendocrine secretory protein 55
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001894 tissue homeostasis IMP
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0006112 energy reserve metabolic process IMP
 biological_processGO:0006306 DNA methylation IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IGI
 biological_processGO:0007606 sensory perception of chemical stimulus IBA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0009966 regulation of signal transduction ISO
 biological_processGO:0030819 obsolete positive regulation of cAMP biosynthetic process ISO
 biological_processGO:0035116 embryonic hindlimb morphogenesis IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0040015 negative regulation of multicellular organism growth IMP
 biological_processGO:0040032 post-embryonic body morphogenesis IMP
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:0043588 skin development IMP
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling ISO
 biological_processGO:0045669 positive regulation of osteoblast differentiation IMP
 biological_processGO:0045672 positive regulation of osteoclast differentiation IMP
 biological_processGO:0048589 developmental growth ISO
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0050890 cognition ISO
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060348 bone development ISO
 biological_processGO:0060789 hair follicle placode formation ISO
 biological_processGO:0070527 platelet aggregation ISO
 biological_processGO:0071107 response to parathyroid hormone ISO
 biological_processGO:0071514 genetic imprinting IMP
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway ISO
 biological_processGO:2000828 regulation of parathyroid hormone secretion IMP
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005834 heterotrimeric G-protein complex TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0031224 intrinsic component of membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032588 trans-Golgi network membrane ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity ISO
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA
 molecular_functionGO:0031698 beta-2 adrenergic receptor binding IBA
 molecular_functionGO:0031748 D1 dopamine receptor binding IBA
 molecular_functionGO:0031852 mu-type opioid receptor binding IBA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity ISO
 molecular_functionGO:0051430 corticotropin-releasing hormone receptor 1 binding IBA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
PKA activation in glucagon signalling
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Prostacyclin signalling through prostacyclin receptor
G alpha (s) signalling events
Glucagon-type ligand receptors
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bdnftm1Jae/Bdnftm2(Ntf5)Jae,Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S4/SvJae

 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Csf1op/Csf1op
Genetic Background: B6C3Fe a/a-Csf1op/J

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dll3pu-J/Dll3pu-J
Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3pu-J/GrsrJ

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Slc5a2-cre)1Tauc/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0000440 domed skull 
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Gnastm1Gwa/Gnas+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: B6.129P2-Bub1tm1.1Tvd

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm1Gwa/Gnas+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Ptprctm1Tyb/Ptprctm1Tyb
Genetic Background: C.129S2-Ptprctm1Tyb

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ptprctm1Tyb/Ptprctm1Tyb
Genetic Background: C.129S2-Ptprctm1Tyb

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Krt1Mhdadsk12/Krt1Mhdadsk12
Genetic Background: C3HeB/FeJ-Krt1Mhdadsk12

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dll3pu-J/Dll3pu-J
Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3pu-J/GrsrJ

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Dll3pu-J/Dll3pu-J
Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3pu-J/GrsrJ

Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Gnastm1Lsw/Gnastm1Lsw
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Lsw/Gnastm1Lsw
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Jae/Bdnftm2(Ntf5)Jae,Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Jae/Bdnftm2(Ntf5)Jae,Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S4/SvJae

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpbtm1Vpo/Cebpbtm1Vpo
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Slc5a2-cre)1Tauc/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ren1tm1Mgfs/Ren1tm1Mgfs
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dll3pu-J/Dll3pu-J
Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3pu-J/GrsrJ

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: GnasOedsml/Gnas+
Genetic Background: involves: 101/H * C3H/HeH * M. m. castaneus

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ren1tm1Mgfs/Ren1tm1Mgfs
Genetic Background: involves: 129P2/OlaHsd

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Dll3pu-J/Dll3pu-J
Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3pu-J/GrsrJ

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0002904 increased circulating parathyroid hormone level "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dll3pu-J/Dll3pu-J
Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3pu-J/GrsrJ

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Slc5a2-cre)1Tauc/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002905 decreased circulating parathyroid hormone level "less than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Gnastm3Lsw/Gnastm3Lsw,Ren1tm2(cre)Gom/Ren1+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0003121 genomic imprinting "phenotype resulting from inactivation of specific loci during gametogenesis, but not encoded by the DNA itself" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0003123 paternal imprinting "specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

Allelic Composition: Gnastm2Kel/Gnas+
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Allelic Composition: Gnastm3Kel/Gnas+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DS/2

 MP:0003353 decreased circulating renin level "reduced blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gnastm3Lsw/Gnastm3Lsw,Ren1tm2(cre)Gom/Ren1+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0003497 insensitivity to parathyroid hormone "no changes in calcium homeostasis in response to endogenous or exogenous hormone" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Krt1Mhdadsk12/Krt1Mhdadsk12
Genetic Background: C3HeB/FeJ-Krt1Mhdadsk12

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0003705 abnormal hypodermis morphology "malformed or atypical condition of the innermost and thickest layer of the skin composed of loose connective tissue containing adipoctyes" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Gwa/Gnas+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0003787 abnormal imprinting "defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gnastm3Kel/Gnas+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DS/2

 MP:0003948 abnormal gas homeostasis "anomaly in the state of equilibrium in the body of gaseous elements in animal tissues or blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0003956 abnormal body size "anomaly in the average body weight, height and/or length of an organism compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Gnastm3Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm3Lsw/Gnastm3Lsw,Ren1tm2(cre)Gom/Ren1+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bub1tm1.1Tvd/Bub1tm1.1Tvd
Genetic Background: B6.129P2-Bub1tm1.1Tvd

 MP:0005406 abnormal heart size "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll3pu-J/Dll3pu-J
Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3pu-J/GrsrJ

 MP:0005440 increased glycogen level "greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0005528 decreased glomerular filtration rate "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ren1tm1Mgfs/Ren1tm1Mgfs
Genetic Background: involves: 129P2/OlaHsd

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0005581 abnormal renin activity "alterated ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gnastm3Lsw/Gnastm3Lsw,Ren1tm2(cre)Gom/Ren1+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt1Mhdadsk12/Krt1Mhdadsk12
Genetic Background: C3HeB/FeJ-Krt1Mhdadsk12

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0006087 increased body mass index "greater than normal average of a measure of weight for height" [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Gnastm3Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: Fmr1tm1Usdn/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gnas/Nespastm1.1Jop/Gnas+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

Allelic Composition: Gnas/Nespastm1.1Jop/Gnas+
Genetic Background: involves: 129S1/Sv * M. spretus

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0009108 increased pancreas weight "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0009294 increased interscapular fat pad weight 
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0009295 decreased interscapular fat pad weight 
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Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0009299 decreased mesenteric fat pad weight 
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0009303 decreased renal fat pad weight 
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Slc5a2-cre)1Tauc/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Slc5a2-cre)1Tauc/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0009673 increased birth weight "increase in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Gnastm3Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0009702 increased birth body size "increase in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll3pu-J/Dll3pu-J
Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3pu-J/GrsrJ

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Gnastm3Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0010316 increased thyroid tumor incidence "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: GnasOedsml/Gnas+
Genetic Background: involves: 101/H * C3H/HeH * M. m. castaneus

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

Allelic Composition: Gnastm3Kel/Gnas+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DS/2

Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Gnastm3Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm1.1Plag/Gnas+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Gnastm1.1Plag/Gnas+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

Allelic Composition: Gnastm1.2Plag/Gnas+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

Allelic Composition: Gnastm1Lsw/Gnastm1Lsw
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0011478 abnormal urine catecholamine level "any anomaly in the urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [MGI:csmith]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0011563 increased urine prostaglandin level "a greater amount of any prostaglandin in the urine compared to the normal state" [MGI:anna]
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Allelic Composition: Gnastm3Lsw/Gnastm3Lsw,Ren1tm2(cre)Gom/Ren1+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011612 increased circulating ghrelin level "greater than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland" [MGI:anna]
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Allelic Composition: Gnastm1.2Plag/Gnas+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Gnastm2Jop/Gnas+
Genetic Background: involves: 129S/SvEv

 MP:0012336 decreased vitamin D level "reduced level of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Slc5a2-cre)1Tauc/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0013585 thymus cortex atrophy "acquired diminution of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0014167 ectopic bone "the appearance of an extra bone structure at an atypical location" [MGI:csmith]
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Allelic Composition: Gnastm1Gwa/Gnas+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023439 Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*  / complex
 ENSMUSG00000025127 Gcgr / Q61606 / Glucagon receptor / P47871*  / reaction
 ENSMUSG00000031390 Avpr2 / O88721 / arginine vasopressin receptor 2 / P30518*  / reaction / complex
 ENSMUSG00000029713 Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*  / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000037727 Avp / P35455 / arginine vasopressin / P01185*  / reaction / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / reaction / complex
 ENSMUSG00000043017 Ptgir / P43252 / Prostacyclin receptor / P43119* / prostaglandin I2 receptor*  / complex / reaction
 ENSMUSG00000027669 Gnb4 / P29387 / guanine nucleotide binding protein (G protein), beta 4 / Q9HAV0* / G protein subunit beta 4*  / complex
 ENSMUSG00000000394 Gcg / P55095 / Glucagon Glicentin Glicentin-related polypeptide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like pepti...  / complex / reaction
 ENSMUSG00000024027 Glp1r / O35659 / Glucagon-like peptide 1 receptor / P43220*  / complex






 

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