ENSMUSG00000037727


Mus musculus

Features
Gene ID: ENSMUSG00000037727
  
Biological name :Avp
  
Synonyms : arginine vasopressin / Avp / P35455
  
Possible biological names infered from orthology : P01185
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 130580620
Gene end: 130582554
  
Corresponding Affymetrix probe sets: 10487685 (MoGene1.0st)   1450794_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035551
NCBI entrez gene - 11998     See in Manteia.
MGI - MGI:88121
RefSeq - NM_009732
RefSeq Peptide - NP_033862
swissprot - P35455
swissprot - Q3UUQ5
Ensembl - ENSMUSG00000037727
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 avpENSDARG00000058567Danio rerio
 oxtENSDARG00000042845Danio rerio
 ENSGALG00000019026Gallus gallus
 AVPENSG00000101200Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Oxt / P35454 / oxytocin / P01178* / oxytocin/neurophysin I prepropeptide*ENSMUSG0000002730154


Protein motifs (from Interpro)
Interpro ID Name
 IPR000981  Neurohypophysial hormone
 IPR022423  Neurohypophysial hormone, conserved site
 IPR036387  Neurohypophysial hormone domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002125 maternal aggressive behavior IEA
 biological_processGO:0003084 positive regulation of systemic arterial blood pressure IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007621 negative regulation of female receptivity IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0007625 grooming behavior IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014049 positive regulation of glutamate secretion IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030819 obsolete positive regulation of cAMP biosynthetic process IDA
 biological_processGO:0031394 positive regulation of prostaglandin biosynthetic process IEA
 biological_processGO:0032849 positive regulation of cellular pH reduction IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035813 regulation of renal sodium excretion IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042538 hyperosmotic salinity response IEA
 biological_processGO:0042711 maternal behavior IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043084 penile erection IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0050880 regulation of blood vessel size IEA
 biological_processGO:0050891 multicellular organismal water homeostasis IEA
 biological_processGO:0051970 negative regulation of transmission of nerve impulse IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070528 protein kinase C signaling IEA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030425 dendrite IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IEA
 molecular_functionGO:0005185 neurohypophyseal hormone activity IEA
 molecular_functionGO:0031894 V1A vasopressin receptor binding IEA
 molecular_functionGO:0031895 V1B vasopressin receptor binding IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA


Pathways (from Reactome)
Pathway description
Vasopressin-like receptors
G alpha (q) signalling events
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
Transport of organic anions
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Avptm1Lja/Avp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Atp6v1dtm1b(EUCOMM)Hmgu/Atp6v1dtm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Atp6v1dtm1b(EUCOMM)Hmgu/Tcp

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Avptm1Lja/Avp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Avptm1Lja/Avp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Avptm1.1(cre)Hze/Avp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Avptm1Lja/Avp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Avptm1Lja/Avp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008846 abnormal supraoptic nucleus morphology "any structural anomaly of a group of cells in the hypothalamus located over the lateral border of the optic tract; neurons produce and transport vasopressin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Avptm1Lja/Avptm1Lja
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Avptm1Chron/Avptm1Chron
Genetic Background: involves: C57BL/6N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Atp6v1dtm1b(EUCOMM)Hmgu/Atp6v1dtm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Atp6v1dtm1b(EUCOMM)Hmgu/Tcp

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Avptm1Lja/Avp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Atp6v1dtm1b(EUCOMM)Hmgu/Atp6v1dtm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Atp6v1dtm1b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025790 Q8R3L5 / Slco3a1 / Solute carrier organic anion transporter family member 3A1 / Q9UIG8*  / reaction
 ENSMUSG00000024858 Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*  / reaction
 ENSMUSG00000031390 Avpr2 / O88721 / arginine vasopressin receptor 2 / P30518*  / complex / reaction
 ENSMUSG00000042249 Grk3 / Q3UYH7 / Beta-adrenergic receptor kinase 2 / P35626* / G protein-coupled receptor kinase 3*  / reaction
 ENSMUSG00000018909 Arrb1 / Q8BWG8 / Beta-arrestin-1 / P49407* / arrestin beta 1*  / complex / reaction
 ENSMUSG00000027523 Gnas / Q9Z0F1 / P63094 / Q6R0H6 / Q6R0H7 / GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus / P84996* / Q5JWF2* / O95467* / P63092* / GNAS complex locus*  / reaction / complex
 ENSMUSG00000026432 Avpr1b / Q9WU02 / Vasopressin V1b receptor / P47901* / arginine vasopressin receptor 1B*  / complex / reaction
 ENSMUSG00000020123 Avpr1a / Q62463 / arginine vasopressin receptor 1A / P37288*  / reaction / complex
 ENSMUSG00000060216 Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*  / reaction / complex






 

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