ENSMUSG00000020123


Mus musculus

Features
Gene ID: ENSMUSG00000020123
  
Biological name :Avpr1a
  
Synonyms : arginine vasopressin receptor 1A / Avpr1a / Q62463
  
Possible biological names infered from orthology : P37288
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D2
Gene start: 122448499
Gene end: 122453452
  
Corresponding Affymetrix probe sets: 10366707 (MoGene1.0st)   1418603_at (Mouse Genome 430 2.0 Array)   1418604_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020323
NCBI entrez gene - 54140     See in Manteia.
MGI - MGI:1859216
RefSeq - NM_016847
RefSeq Peptide - NP_058543
swissprot - Q3U1H9
swissprot - Q62463
Ensembl - ENSMUSG00000020123
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 avpr1aaENSDARG00000077083Danio rerio
 avpr1abENSDARG00000045788Danio rerio
 AVPR1AENSGALG00000040567Gallus gallus
 AVPR1AENSG00000166148Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Avpr1b / Q9WU02 / Vasopressin V1b receptor / P47901* / arginine vasopressin receptor 1B*ENSMUSG0000002643247
Oxtr / P97926 / Oxytocin receptor / P30559*ENSMUSG0000004911246
Avpr2 / O88721 / arginine vasopressin receptor 2 / P30518*ENSMUSG0000003139035
Npsr1 / Q8BZP8 / Neuropeptide S receptor / Q6W5P4* / neuropeptide S receptor 1*ENSMUSG0000004365924
Gnrhr / Q01776 / gonadotropin releasing hormone receptor / P30968*ENSMUSG0000002925521
Gpr19 / Q61121 / Probable G-protein coupled receptor 19 / Q15760* / G protein-coupled receptor 19*ENSMUSG0000003264120


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001224  Vasopressin V1A receptor
 IPR001817  Vasopressin receptor
 IPR015076  Domain of unknown function DUF1856
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001992 regulation of systemic arterial blood pressure by vasopressin IGI
 biological_processGO:0002125 maternal aggressive behavior IEA
 biological_processGO:0003084 positive regulation of systemic arterial blood pressure IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007621 negative regulation of female receptivity IEA
 biological_processGO:0007625 grooming behavior IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010035 response to inorganic substance IEA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0014049 positive regulation of glutamate secretion IEA
 biological_processGO:0014902 myotube differentiation IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031394 positive regulation of prostaglandin biosynthetic process IEA
 biological_processGO:0032849 positive regulation of cellular pH reduction IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0042631 cellular response to water deprivation IEA
 biological_processGO:0042711 maternal behavior IEA
 biological_processGO:0042713 sperm ejaculation IEA
 biological_processGO:0043084 penile erection IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0051970 negative regulation of transmission of nerve impulse IEA
 biological_processGO:1901652 response to peptide IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005000 vasopressin receptor activity IBA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0031894 V1A vasopressin receptor binding IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Vasopressin-like receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000250 abnormal vasoconstriction "anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
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Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbn1tm2Rmz/Fbn1tm2Rmz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Fbn1tm2Rmz/Fbn1tm2Rmz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0001629 abnormal heart rate "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0001633 poor circulation "insufficient movement of blood throughout the body" [MGI:cls, J:45302]
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Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbn1tm2Rmz/Fbn1tm2Rmz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fbn1tm2Rmz/Fbn1tm2Rmz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004184 abnormal baroreceptor physiology "anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0005345 abnormal circulating corticosterone level "anomalous blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0005523 decreased circulating atrial natriuretic factor "less than the normal concentration of this peptide hormone in the blood; it regulates the water-electrolyte balance and acts as a vasodilator" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Fbn1tm2Rmz/Fbn1tm2Rmz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbn1tm2Rmz/Fbn1tm2Rmz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbn1tm2Rmz/Fbn1tm2Rmz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000037727 Avp / P35455 / arginine vasopressin / P01185*  / reaction / complex






 

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