Manteia - Molecule gene

ENSMUSG00000029255

Mus musculus

Features

Gene ID:	ENSMUSG00000029255

Biological name :	Gnrhr

Synonyms :	Gnrhr / gonadotropin releasing hormone receptor / Q01776

Possible biological names infered from orthology :	P30968

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	E1
Gene start:	86180754
Gene end:	86197901

Corresponding Affymetrix probe sets:	10530944 (MoGene1.0st) 1421665_a_at (Mouse Genome 430 2.0 Array) 1427694_at (Mouse Genome 430 2.0 Array) 1427731_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000031172 Ensembl peptide - ENSMUSP00000092238 Ensembl peptide - ENSMUSP00000108999 NCBI entrez gene - 14715 See in Manteia. MGI - MGI:95790 RefSeq - XM_017320667 RefSeq - NM_001310651 RefSeq - NM_001310653 RefSeq - NM_010323 RefSeq Peptide - NP_001297580 RefSeq Peptide - NP_001297582 RefSeq Peptide - NP_034453 swissprot - Q01776 swissprot - Q6P8H4 swissprot - D3Z6P7 Ensembl - ENSMUSG00000029255

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
GNRHR	ENSG00000109163	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Avpr1a / Q62463 / arginine vasopressin receptor 1A / P37288*	ENSMUSG00000020123	27
Oxtr / P97926 / Oxytocin receptor / P30559*	ENSMUSG00000049112	25
Avpr1b / Q9WU02 / Vasopressin V1b receptor / P47901* / arginine vasopressin receptor 1B*	ENSMUSG00000026432	23
Avpr2 / O88721 / arginine vasopressin receptor 2 / P30518*	ENSMUSG00000031390	23
Npsr1 / Q8BZP8 / Neuropeptide S receptor / Q6W5P4* / neuropeptide S receptor 1*	ENSMUSG00000043659	21
Gpr19 / Q61121 / Probable G-protein coupled receptor 19 / Q15760* / G protein-coupled receptor 19*	ENSMUSG00000032641	19

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR001658	Gonadotrophin-releasing hormone receptor family
IPR017452	GPCR, rhodopsin-like, 7TM
IPR027982	Gonadotropin-releasing hormone receptor

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0097211	cellular response to gonadotropin-releasing hormone	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0004968	gonadotropin-releasing hormone receptor activity	IEA
molecular_function	GO:0016500	protein-hormone receptor activity	IEA
molecular_function	GO:0042277	peptide binding	IBA

Pathways (from Reactome)

Pathway description

Hormone ligand-binding receptors

G alpha (q) signalling events

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001116	small gonad	"reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified
MP:0001119	abnormal female reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified
MP:0001121	uterine hypoplasia	"reduced size of the uterus due to decreased cell number" [J:45065]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Cnga2^tm2Reed/Y Genetic Background: involves: 129/Sv * BALB/cJ Allelic Composition: Gnrhr^tm1.1Bhr/Gnrhr^tm1.1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J Allelic Composition: Gnrhr^tm1Bhr/Gnrhr^tm1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0001127	small ovary	"reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified Allelic Composition: Gnrhr^tm1Bhr/Gnrhr^tm1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0001129	impaired ovarian folliculogenesis	"a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001134	absent corpora lutea	"missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified
MP:0001143	constricted vaginal opening	"shrunken, narrowed external vaginal opening" [J:50844]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001145	abnormal male reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified Allelic Composition: Gnrhr^tm1.1Bhr/Gnrhr^tm1.1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cnga2^tm2Reed/Y Genetic Background: involves: 129/Sv * BALB/cJ
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Gnrhr^tm1.1Bhr/Gnrhr^tm1.1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J Allelic Composition: Gnrhr^tm1Bhr/Gnrhr^tm1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0001153	small seminiferous tubules	"reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Gnrhr^tm1Bhr/Gnrhr^tm1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0001155	arrest of spermatogenesis	"block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]	Show Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0001157	small seminal gland	"reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Cnga2^tm2Reed/Y Genetic Background: involves: 129/Sv * BALB/cJ
MP:0001919	abnormal reproductive system physiology	"anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gnrhr^tm1Bhr/Gnrhr^tm1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Pla2g5^tm1Jarm/Pla2g5^tm1Jarm Genetic Background: B6.129-Pla2g5^tm1Jarm
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001927	abnormal oestrous cycle (sensu Rodentia)	"failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Pla2g5^tm1Jarm/Pla2g5^tm1Jarm Genetic Background: B6.129-Pla2g5^tm1Jarm
MP:0001929	abnormal gametogenesis	"defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]	Show Allelic Composition: Gnrhr^tm1.1Bhr/Gnrhr^tm1.1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0002160	abnormal reproductive system morphology	"structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gnrhr^tm1Bhr/Gnrhr^tm1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdca8^tm1Tatn/Cdca8^tm1Tatn,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
MP:0002216	abnormal seminiferous tubule morphology	"malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0002286	cryptorchism	"failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified
MP:0002636	delayed vaginal opening	"the opening of the genital canal in a female occuring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0002680	decreased number of corpora lutea	"fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gnrhr^tm1.1Bhr/Gnrhr^tm1.1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Gnrhr^tm1Bhr/Gnrhr^tm1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0002716	small preputial glands	"reduced size of the sebaceous glands of the corona and neck of the glans penis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator, J:82312]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0002773	decreased circulating luteinizing hormone level	"lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Gnrhr^{tm1(GNRHR1)Xen}/Gnrhr^{tm1(GNRHR1)Xen} Genetic Background: involves: C57BL/6 * C57BL/6JOlaHsd Allelic Composition: Gnrhr^tm1.1Bhr/Gnrhr^tm1.1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Gnrhr^{tm1(GNRHR1)Xen}/Gnrhr^{tm1(GNRHR1)Xen} Genetic Background: involves: C57BL/6 * C57BL/6JOlaHsd
MP:0002786	abnormal Leydig cell morphology	"malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0002790	decreased circulating follicle stimulating hormone level	"less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Gnrhr^tm1.1Bhr/Gnrhr^tm1.1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0003363	decreased circulating gonadotropin level	"less than the normal blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis " [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gnrhr^tm1.1Bhr/Gnrhr^tm1.1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0003510	decreased circulating levels of dihydrotestosterone	"reduction in the blood concentration of this potent androgenic metabolite of testosterone" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified
MP:0003699	abnormal female reproductive system physiology	"anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0003969	abnormal lutenizing hormone level		Show Allelic Composition: Gnrhr^{tm1(GNRHR1)Xen}/Gnrhr^{tm1(GNRHR1)Xen} Genetic Background: involves: C57BL/6 * C57BL/6JOlaHsd
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0004856	decreased ovary weight	"reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0004930	small epididymis	"decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0005130	decreased follicle stimulating hormone level	"less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified
MP:0005132	decreased luteinizing hormone level	"lower than normal concentration of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified
MP:0005164	abnormal response to injury	"anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gnrhr^{tm1(GNRHR1)Xen}/Gnrhr^{tm1(GNRHR1)Xen} Genetic Background: involves: C57BL/6 * C57BL/6JOlaHsd
MP:0005181	decreased circulating estradiol level	"less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0005182	increased circulating estradiol level	"greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gnrhr^{tm1(GNRHR1)Xen}/Gnrhr^{tm1(GNRHR1)Xen} Genetic Background: involves: C57BL/6 * C57BL/6JOlaHsd
MP:0005185	decreased circulating progesterone level	"less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0005188	small penis	"in comparison to the norm, reduced size of the organ of copulation and urination in the male" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0005189	abnormal anogenital distance	"in comparison to the norm, aberration in the measure of the length of space from the genitals to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified
MP:0005418	abnormal circulating hormone level	"anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified
MP:0005578	teratozoospermia	"presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]	Show Allelic Composition: Gnrhr^tm1Bhr/Gnrhr^tm1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0006379	abnormal spermatocyte morphology	"anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0008261	arrest of male meiosis	"cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified
MP:0008871	abnormal ovarian follicle number	"abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnrhr^tm1Bhr/Gnrhr^tm1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0008892	abnormal sperm flagellum	"any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]	Show Allelic Composition: Gnrhr^tm1Bhr/Gnrhr^tm1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0009006	prolonged estrous cycle	"increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnrhr^{tm1(GNRHR1)Xen}/Gnrhr^{tm1(GNRHR1)Xen} Genetic Background: involves: C57BL/6 * C57BL/6JOlaHsd
MP:0009009	absent estrous cycle	"failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Gnrhr^hh/Gnrhr^hh Genetic Background: involves: C57BL/6
MP:0009017	prolonged estrus	"increase in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnrhr^tm1.1Bhr/Gnrhr^tm1.1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0009020	prolonged metestrus	"increase in the length of the metestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnrhr^{tm1(GNRHR1)Xen}/Gnrhr^{tm1(GNRHR1)Xen} Genetic Background: involves: C57BL/6 * C57BL/6JOlaHsd
MP:0009081	thin uterus	"reduced thickness or depth of the female muscular organ of gestation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0009199	abnormal external male genitalia morphology	"any structural anomaly of the external masculine genital organs, including the penis and scrotum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0009205	abnormal internal male genitalia morphology	"any structural anomaly of the internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0009209	abnormal internal female genitalia morphology	"any structural anomaly of the internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0009234	absent sperm head	"absence of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnrhr^tm1Bhr/Gnrhr^tm1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0009363	abnormal secondary ovarian follicle morphology	"any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified
MP:0011128	increased secondary ovarian follicle number	"greater than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:csmith]	Show Allelic Composition: Gnrhr^tm1.1Bhr/Gnrhr^tm1.1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000015812	Gnrh1 / P13562 / gonadotropin releasing hormone 1 / P01148*	/ complex / reaction

0 s.

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