ENSMUSG00000049112


Mus musculus

Features
Gene ID: ENSMUSG00000049112
  
Biological name :Oxtr
  
Synonyms : Oxtr / Oxytocin receptor / P97926
  
Possible biological names infered from orthology : P30559
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: E3
Gene start: 112473683
Gene end: 112489943
  
Corresponding Affymetrix probe sets: 10546829 (MoGene1.0st)   1426000_at (Mouse Genome 430 2.0 Array)   1440888_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145300
Ensembl peptide - ENSMUSP00000051132
NCBI entrez gene - 18430     See in Manteia.
MGI - MGI:109147
RefSeq - NM_001081147
RefSeq - XM_006505723
RefSeq Peptide - NP_001074616
swissprot - A0A0N4SVY6
swissprot - P97926
Ensembl - ENSMUSG00000049112
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oxtrENSDARG00000033956Danio rerio
 oxtrlENSDARG00000044175Danio rerio
 OXTRENSGALG00000003138Gallus gallus
 OXTRENSG00000180914Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Avpr1a / Q62463 / arginine vasopressin receptor 1A / P37288*ENSMUSG0000002012350
Avpr1b / Q9WU02 / Vasopressin V1b receptor / P47901* / arginine vasopressin receptor 1B*ENSMUSG0000002643250
Avpr2 / O88721 / arginine vasopressin receptor 2 / P30518*ENSMUSG0000003139038
Npsr1 / Q8BZP8 / Neuropeptide S receptor / Q6W5P4* / neuropeptide S receptor 1*ENSMUSG0000004365926
Gnrhr / Q01776 / gonadotropin releasing hormone receptor / P30968*ENSMUSG0000002925521
Gpr19 / Q61121 / Probable G-protein coupled receptor 19 / Q15760* / G protein-coupled receptor 19*ENSMUSG0000003264119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001817  Vasopressin receptor
 IPR002062  Oxytocin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001967 suckling behavior IEA
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0001992 regulation of systemic arterial blood pressure by vasopressin IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007595 lactation IBA
 biological_processGO:0007613 memory IEA
 biological_processGO:0010701 positive regulation of norepinephrine secretion IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0030431 sleep IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0034059 response to anoxia IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042711 maternal behavior IEA
 biological_processGO:0042713 sperm ejaculation IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0044058 regulation of digestive system process IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045777 positive regulation of blood pressure IGI
 biological_processGO:0045907 positive regulation of vasoconstriction IBA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060137 maternal process involved in parturition IEA
 biological_processGO:0060406 positive regulation of penile erection IEA
 biological_processGO:0060455 negative regulation of gastric acid secretion IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070474 positive regulation of uterine smooth muscle contraction IEA
 biological_processGO:1901652 response to peptide IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004990 oxytocin receptor activity IBA
 molecular_functionGO:0005000 vasopressin receptor activity IBA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Vasopressin-like receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Oxtrtm1.1Wsy/Oxtrtm1.1Wsy,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni
Genetic Background: Not Specified

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni
Genetic Background: Not Specified

Allelic Composition: Oxtrtm1.1Wsy/Oxtrtm1.1Wsy,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

Allelic Composition: Oxtrtm1.2Wsy/Oxtrtm1.2Wsy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

Allelic Composition: Oxtrtm1Knis/Oxtrtm1Knis
Genetic Background: B6N.129P2-Oxtrtm1Knis

 MP:0001384 abnormal pup retrieval "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni
Genetic Background: Not Specified

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni
Genetic Background: Not Specified

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni
Genetic Background: Not Specified

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Oxtrtm1Knis/Oxtrtm1Knis
Genetic Background: B6N.129P2-Oxtrtm1Knis

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oxtrtm1.1Wsy/Oxtrtm1.1Wsy,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003838 abnormal milk ejection "impaired milk ejection reflex in response to suckling during lactation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:36926]
Show

Allelic Composition: Oxtrtm1.2Wsy/Oxtrtm1.2Wsy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0009326 abnormal maternal crouching "females do not assume a position over young that facilitates suckling behavior" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni
Genetic Background: Not Specified

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni
Genetic Background: Not Specified

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
Show

Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027301 Oxt / P35454 / oxytocin / P01178* / oxytocin/neurophysin I prepropeptide*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr