ENSMUSG00000027301


Mus musculus

Features
Gene ID: ENSMUSG00000027301
  
Biological name :Oxt
  
Synonyms : Oxt / oxytocin / P35454
  
Possible biological names infered from orthology : oxytocin/neurophysin I prepropeptide / P01178
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 130576173
Gene end: 130577054
  
Corresponding Affymetrix probe sets: 10476192 (MoGene1.0st)   1420556_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028764
NCBI entrez gene - 18429     See in Manteia.
MGI - MGI:97453
RefSeq - NM_011025
RefSeq Peptide - NP_035155
swissprot - P35454
swissprot - Q545V4
Ensembl - ENSMUSG00000027301
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 avpENSDARG00000058567Danio rerio
 oxtENSDARG00000042845Danio rerio
 ENSGALG00000019026Gallus gallus
 OXTENSG00000101405Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Avp / P35455 / arginine vasopressin / P01185*ENSMUSG0000003772773


Protein motifs (from Interpro)
Interpro ID Name
 IPR000981  Neurohypophysial hormone
 IPR022423  Neurohypophysial hormone, conserved site
 IPR036387  Neurohypophysial hormone domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0002125 maternal aggressive behavior IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0007625 grooming behavior IEA
 biological_processGO:0009612 response to mechanical stimulus ISS
 biological_processGO:0009744 response to sucrose IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010701 positive regulation of norepinephrine secretion IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0030431 sleep IEA
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032308 positive regulation of prostaglandin secretion IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0034695 response to prostaglandin E IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035811 negative regulation of urine volume IEA
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042538 hyperosmotic salinity response IEA
 biological_processGO:0042711 maternal behavior IEA
 biological_processGO:0042713 sperm ejaculation IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0042756 drinking behavior IEA
 biological_processGO:0043207 response to external biotic stimulus ISS
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0044058 regulation of digestive system process IEA
 biological_processGO:0045472 response to ether IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045778 positive regulation of ossification IEA
 biological_processGO:0045925 positive regulation of female receptivity IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0050806 positive regulation of synaptic transmission IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0060179 male mating behavior IEA
 biological_processGO:0060406 positive regulation of penile erection IEA
 biological_processGO:0060450 positive regulation of hindgut contraction IEA
 biological_processGO:0060455 negative regulation of gastric acid secretion IEA
 biological_processGO:0070474 positive regulation of uterine smooth muscle contraction IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0043195 terminal bouton IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IEA
 molecular_functionGO:0005185 neurohypophyseal hormone activity IEA
 molecular_functionGO:0031855 oxytocin receptor binding IEA


Pathways (from Reactome)
Pathway description
Vasopressin-like receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Crhtm1.1(cre)Dolsn/Crh+,Mc4rtm1Lowl/Mc4rtm1Lowl,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0001422 abnormal drinking behavior "an altered pattern of fluid consumption or altered preference for particular fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0001432 abnormal food preference "the desire to eat more or less food than average, or to eat unusual foods" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0001460 abnormal olfactory -discrimination memory "defects in the ability to exhibit a differential response to olfactory stimuli that is achieved by the reinforcement of the desired response for each particular olfactory stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
Show

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0002907 abnormal parturition "defect in the process of labor and delivery in female animals " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Oxttm2Ljm/Oxttm2Ljm
Genetic Background: B6.129S2-Oxttm2Ljm

Allelic Composition: Oxttm3Ljm/Oxttm3Ljm
Genetic Background: either: B6.129S2-Oxttm3Ljm or B6.129S6-Oxttm3Ljm

 MP:0003838 abnormal milk ejection "impaired milk ejection reflex in response to suckling during lactation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:36926]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0004184 abnormal baroreceptor physiology "anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005656 decreased aggression "when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxttm2Ljm/Oxttm2Ljm
Genetic Background: B6.129S2-Oxttm2Ljm

Allelic Composition: Oxttm3Ljm/Oxttm3Ljm
Genetic Background: either: B6.129S2-Oxttm3Ljm or B6.129S6-Oxttm3Ljm

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011957 decreased compensatory feeding amount "decreased amount of food consumed after a period of fasting" [MGI:csmith]
Show

Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0013718 galactostasis "abnormal accumulation of milk within the mammary gland alveoli and ducts due to failure of ejection (letdown) from the gland; may be associated with nipple anatomic abnormalities" [MGI:Anna]
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Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

Allelic Composition: Oxttm2Ljm/Oxttm2Ljm
Genetic Background: B6.129S2-Oxttm2Ljm

Allelic Composition: Oxttm3Ljm/Oxttm3Ljm
Genetic Background: either: B6.129S2-Oxttm3Ljm or B6.129S6-Oxttm3Ljm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000049112 Oxtr / P97926 / Oxytocin receptor / P30559*  / complex / reaction






 

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