ENSMUSG00000031390


Mus musculus

Features
Gene ID: ENSMUSG00000031390
  
Biological name :Avpr2
  
Synonyms : arginine vasopressin receptor 2 / Avpr2 / O88721
  
Possible biological names infered from orthology : P30518
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 73892102
Gene end: 73895502
  
Corresponding Affymetrix probe sets: 10600310 (MoGene1.0st)   1450277_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033765
Ensembl peptide - ENSMUSP00000099011
Ensembl peptide - ENSMUSP00000110037
NCBI entrez gene - 12000     See in Manteia.
MGI - MGI:88123
RefSeq - XM_017318365
RefSeq - NM_001276298
RefSeq - NM_001276299
RefSeq - NM_019404
RefSeq - XM_006527756
RefSeq Peptide - NP_062277
RefSeq Peptide - NP_001263227
RefSeq Peptide - NP_001263228
swissprot - Q3SWS4
swissprot - Q3SWS1
swissprot - O88721
swissprot - Q3KNZ4
Ensembl - ENSMUSG00000031390
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 avpr2aaENSDARG00000007436Danio rerio
 avpr2abENSDARG00000029219Danio rerio
 AVPR2ENSGALG00000009497Gallus gallus
 AVPR2ENSG00000126895Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Avpr1b / Q9WU02 / Vasopressin V1b receptor / P47901* / arginine vasopressin receptor 1B*ENSMUSG0000002643241
Avpr1a / Q62463 / arginine vasopressin receptor 1A / P37288*ENSMUSG0000002012339
Oxtr / P97926 / Oxytocin receptor / P30559*ENSMUSG0000004911239
Npsr1 / Q8BZP8 / Neuropeptide S receptor / Q6W5P4* / neuropeptide S receptor 1*ENSMUSG0000004365924
Gnrhr / Q01776 / gonadotropin releasing hormone receptor / P30968*ENSMUSG0000002925520
Gpr19 / Q61121 / Probable G-protein coupled receptor 19 / Q15760* / G protein-coupled receptor 19*ENSMUSG0000003264118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000161  Vasopressin V2 receptor
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001817  Vasopressin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001992 regulation of systemic arterial blood pressure by vasopressin IBA
 biological_processGO:0003084 positive regulation of systemic arterial blood pressure IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0032609 interferon-gamma production IMP
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0034097 response to cytokine IMP
 biological_processGO:0035811 negative regulation of urine volume IEA
 biological_processGO:0035814 negative regulation of renal sodium excretion IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IBA
 biological_processGO:1901652 response to peptide IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005000 vasopressin receptor activity IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Avpr2tm1Jwe/Avpr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CF-1

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024858 Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*  / reaction
 ENSMUSG00000060216 Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*  / reaction / complex
 ENSMUSG00000037727 Avp / P35455 / arginine vasopressin / P01185*  / complex / reaction
 ENSMUSG00000018909 Arrb1 / Q8BWG8 / Beta-arrestin-1 / P49407* / arrestin beta 1*  / complex / reaction
 ENSMUSG00000027523 Gnas / Q9Z0F1 / P63094 / Q6R0H6 / Q6R0H7 / GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus / P84996* / Q5JWF2* / O95467* / P63092* / GNAS complex locus*  / reaction / complex
 ENSMUSG00000042249 Grk3 / Q3UYH7 / Beta-adrenergic receptor kinase 2 / P35626* / G protein-coupled receptor kinase 3*  / reaction






 

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