Manteia

ENSMUSG00000042249

Mus musculus

Features

Gene ID:	ENSMUSG00000042249

Biological name :	Grk3

Synonyms :	Beta-adrenergic receptor kinase 2 / Grk3 / Q3UYH7

Possible biological names infered from orthology :	G protein-coupled receptor kinase 3 / P35626

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	F
Gene start:	112910482
Gene end:	113015791

Corresponding Affymetrix probe sets:	10532630 (MoGene1.0st) 1434450_s_at (Mouse Genome 430 2.0 Array) 1439178_at (Mouse Genome 430 2.0 Array) 1440801_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000070445 Ensembl peptide - ENSMUSP00000142926 Ensembl peptide - ENSMUSP00000142968 Ensembl peptide - ENSMUSP00000143427 NCBI entrez gene - 320129 See in Manteia. MGI - MGI:87941 RefSeq - NM_001285806 RefSeq - NM_177078 RefSeq Peptide - NP_001272735 RefSeq Peptide - NP_796052 swissprot - Q8BX71 swissprot - Q3UYH7 swissprot - Q8BVT9 swissprot - A0A0G2JEW1 Ensembl - ENSMUSG00000042249

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*	ENSMUSG00000024858	81
Grk6 / O70293 / G protein-coupled receptor kinase 6 / P43250*	ENSMUSG00000074886	31
Grk5 / Q8VEB1 / G protein-coupled receptor kinase 5 / P34947*	ENSMUSG00000003228	29
Grk4 / O70291 / G protein-coupled receptor kinase 4 / P32298*	ENSMUSG00000052783	27
Grk1 / G protein-coupled receptor kinase 1 / Q15835*	ENSMUSG00000031450	26

Protein motifs (from Interpro)

Interpro ID	Name
IPR000239	GPCR kinase
IPR000719	Protein kinase domain
IPR000961	AGC-kinase, C-terminal
IPR001849	Pleckstrin homology domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR011993	PH-like domain superfamily
IPR016137	RGS domain
IPR017441	Protein kinase, ATP binding site
IPR036305	RGS domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0031623	receptor internalization	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	IEA
molecular_function	GO:0004703	G-protein coupled receptor kinase activity	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0047696	beta-adrenergic receptor kinase activity	IEA

Pathways (from Reactome)

Pathway description

G alpha (s) signalling events

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001983	abnormal olfactory system physiology	"abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mertk^tm1Grl/Mertk^tm1Grl,Tyro3^tm1Grl/Tyro3^tm1Grl Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000037727	Avp / P35455 / arginine vasopressin / P01185*	/ reaction
ENSMUSG00000031390	Avpr2 / O88721 / arginine vasopressin receptor 2 / P30518*	/ reaction
ENSMUSG00000045730	Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr