ENSMUSG00000003228


Mus musculus

Features
Gene ID: ENSMUSG00000003228
  
Biological name :Grk5
  
Synonyms : G protein-coupled receptor kinase 5 / Grk5 / Q8VEB1
  
Possible biological names infered from orthology : P34947
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D3
Gene start: 60889749
Gene end: 61092553
  
Corresponding Affymetrix probe sets: 10464425 (MoGene1.0st)   1449514_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003313
NCBI entrez gene - 14773     See in Manteia.
MGI - MGI:109161
RefSeq - XM_017318066
RefSeq - NM_018869
RefSeq - XM_006526697
RefSeq - XM_011247149
RefSeq Peptide - NP_061357
swissprot - Q3TST4
swissprot - Q8VEB1
Ensembl - ENSMUSG00000003228
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grk5ENSDARG00000032801Danio rerio
 grk5lENSDARG00000078815Danio rerio
 GRK5ENSGALG00000009403Gallus gallus
 GRK5ENSG00000198873Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grk6 / O70293 / G protein-coupled receptor kinase 6 / P43250*ENSMUSG0000007488669
Grk4 / O70291 / G protein-coupled receptor kinase 4 / P32298*ENSMUSG0000005278362
Grk1 / G protein-coupled receptor kinase 1 / Q15835*ENSMUSG0000003145044
Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*ENSMUSG0000002485834
Grk3 / Q3UYH7 / Beta-adrenergic receptor kinase 2 / P35626* / G protein-coupled receptor kinase 3*ENSMUSG0000004224934


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR011009  Protein kinase-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007217 tachykinin receptor signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0047696 beta-adrenergic receptor kinase activity IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000622 increased salivation "greater than normal amounts of flowing saliva" [J:65032, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ryr2tm2Amks/Ryr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Grk5tm1Rjl/Grk5tm1Rjl
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Xrcc1tm1Pmc/Xrcc1tm1Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ryr2tm2Amks/Ryr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Grk5tm1Rjl/Grk5tm1Rjl
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045730 Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*  / reaction / complex






 

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