Manteia

ENSMUSG00000052783

Mus musculus

Features

Gene ID:	ENSMUSG00000052783

Biological name :	Grk4

Synonyms :	G protein-coupled receptor kinase 4 / Grk4 / O70291

Possible biological names infered from orthology :	P32298

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	B2
Gene start:	34660379
Gene end:	34755305

Corresponding Affymetrix probe sets:	10521243 (MoGene1.0st) 1420355_at (Mouse Genome 430 2.0 Array) 1454152_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000001112 Ensembl peptide - ENSMUSP00000074223 Ensembl peptide - ENSMUSP00000122826 NCBI entrez gene - 14772 See in Manteia. MGI - MGI:95801 RefSeq - XM_017320672 RefSeq - NM_001080743 RefSeq - NM_019497 RefSeq - XM_006503741 RefSeq - XM_006503742 RefSeq - XM_017320669 RefSeq - XM_017320670 RefSeq - XM_017320671 RefSeq Peptide - NP_001074212 RefSeq Peptide - NP_062370 swissprot - O70291 swissprot - Q8BP13 swissprot - F7BEP0 Ensembl - ENSMUSG00000052783

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Grk5 / Q8VEB1 / G protein-coupled receptor kinase 5 / P34947*	ENSMUSG00000003228	64
Grk6 / O70293 / G protein-coupled receptor kinase 6 / P43250*	ENSMUSG00000074886	63
Grk1 / G protein-coupled receptor kinase 1 / Q15835*	ENSMUSG00000031450	46
Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*	ENSMUSG00000024858	34
Grk3 / Q3UYH7 / Beta-adrenergic receptor kinase 2 / P35626* / G protein-coupled receptor kinase 3*	ENSMUSG00000042249	33

Protein motifs (from Interpro)

Interpro ID	Name
IPR000239	GPCR kinase
IPR000719	Protein kinase domain
IPR000961	AGC-kinase, C-terminal
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR016137	RGS domain
IPR017441	Protein kinase, ATP binding site
IPR036305	RGS domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway	IEA
biological_process	GO:0002031	G-protein coupled receptor internalization	IEA
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0031623	receptor internalization	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005938	cell cortex	IEA
cellular_component	GO:0030425	dendrite	IEA
cellular_component	GO:0043025	neuronal cell body	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	IEA
molecular_function	GO:0004703	G-protein coupled receptor kinase activity	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0050254	rhodopsin kinase activity	IEA

Pathways (from Reactome)

Pathway description

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Xrcc1^tm1Pmc/Xrcc1^tm1Pmc,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000030324	Rho / P15409 / Rhodopsin / P08100*	/ reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr