ENSMUSG00000030324


Mus musculus

Features
Gene ID: ENSMUSG00000030324
  
Biological name :Rho
  
Synonyms : P15409 / Rho / Rhodopsin
  
Possible biological names infered from orthology : P08100
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 115931748
Gene end: 115940036
  
Corresponding Affymetrix probe sets: 10540984 (MoGene1.0st)   10540991 (MoGene1.0st)   1425171_at (Mouse Genome 430 2.0 Array)   1425172_at (Mouse Genome 430 2.0 Array)   1451617_at (Mouse Genome 430 2.0 Array)   1451618_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032471
Ensembl peptide - ENSMUSP00000145464
Ensembl peptide - ENSMUSP00000144952
Ensembl peptide - ENSMUSP00000144768
NCBI entrez gene - 212541     See in Manteia.
MGI - MGI:97914
RefSeq - XM_006505860
RefSeq - XM_017321493
RefSeq - XM_006505861
RefSeq - NM_145383
RefSeq Peptide - NP_663358
swissprot - P15409
swissprot - A0A0N4SWC6
swissprot - A0A0N4SUP8
swissprot - A0A0N4SV48
Ensembl - ENSMUSG00000030324
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhoENSDARG00000002193Danio rerio
 rhodopsinENSDARG00000111860Danio rerio
 rholENSDARG00000070666Danio rerio
 RHOENSGALG00000020745Gallus gallus
 RHOENSG00000163914Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Opn1sw / P51491 / Short-wave-sensitive opsin 1 / P03999* / opsin 1, short wave sensitive*ENSMUSG0000005883144
Opn1mw / O35599 / Medium-wave-sensitive opsin 1 / P0DN78* / OPN1LW* / P04000* / P04001* / P0DN77* / OPN1MW2* / OPN1MW3* / opsin 1, long wave sensitive* / opsin 1, medium wave sensitive* / ...ENSMUSG0000003139440
Opn3 / Q9WUK7 / Opsin-3 / Q9H1Y3*ENSMUSG0000002652530
Opn4 / Q9QXZ9 / Melanopsin / Q9UHM6* / opsin 4*ENSMUSG0000002179927
Rrh / O35214 / retinal pigment epithelium derived rhodopsin homolog / O14718*ENSMUSG0000002801224
Opn5 / Q6VZZ7 / Opsin-5 / Q6U736*ENSMUSG0000004397222


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000732  Rhodopsin
 IPR001760  Opsin
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR019477  Rhodopsin, N-terminal
 IPR027430  Visual pigments (opsins) retinal binding site
 IPR037114  Rhodopsin, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0007602 phototransduction IEA
 biological_processGO:0009416 response to light stimulus IMP
 biological_processGO:0009583 detection of light stimulus IMP
 biological_processGO:0016038 absorption of visible light ISS
 biological_processGO:0016056 rhodopsin mediated signaling pathway ISS
 biological_processGO:0018298 protein-chromophore linkage IEA
 biological_processGO:0045494 photoreceptor cell maintenance IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0050953 sensory perception of light stimulus IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0071482 cellular response to light stimulus IMP
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042622 photoreceptor outer segment membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0060342 photoreceptor inner segment membrane IEA
 cellular_componentGO:0097381 photoreceptor disc membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005502 11-cis retinal binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008020 G-protein coupled photoreceptor activity ISS
 molecular_functionGO:0009881 photoreceptor activity IEA
 molecular_functionGO:0030507 spectrin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
The canonical retinoid cycle in rods (twilight vision)
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
G alpha (i) signalling events
Opsins
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rhotm1Phm/Rho+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Rhotm2(RHO/GFP)Jhw/Rhotm2(RHO/GFP)Jhw
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Rhotm1.1Eye/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: RhoR3/RhoR3
Genetic Background: C57BL/6J-RhoR3

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Msh2tm1Mtn/Msh2tm1Mtn
Genetic Background: involves: C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rhotm2.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

Allelic Composition: Rhotm1.1(RHO*)Akgr/Rho+
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * FVB/N

Allelic Composition: Rhotm1.1Eye/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: RhoTvrm144/Rho+
Genetic Background: involves: C57BL/6J

Allelic Composition: RhoTvrm144/RhoTvrm144
Genetic Background: involves: C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Rhotm1Jlem/Rhotm1Jlem
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Rhotm2(RHO/GFP)Jhw/Rhotm2(RHO/GFP)Jhw
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc * FVB)

Allelic Composition: Rhotm2(RHO/GFP)Jhw/Rho+
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc * FVB)

Allelic Composition: Pde6brd1/Pde6brd1,Rhotm2(RHO/GFP)Jhw/Rho+
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc * FVB)

Allelic Composition: Rhotm3(RHO/GFP)Jhw/Rhotm3(RHO/GFP)Jhw
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc)

Allelic Composition: Rhotm3(RHO/GFP)Jhw/Rho+
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc)

Allelic Composition: Rhotm2Jlem/Rhotm2Jlem
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Rhotm2(RHO/GFP)Jhw/Rhotm2(RHO/GFP)Jhw
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: RhoR3/Rho+
Genetic Background: C57BL/6J-RhoR3

Allelic Composition: RhoR3/RhoR3
Genetic Background: C57BL/6J-RhoR3

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm1.1Kpal/Rho+,Rpe65450L/Rpe65450M
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rhotm4.1(RHO*/EGFP)Jhw
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

Allelic Composition: Rhotm1.1(RHO*)Akgr/Rhotm1.1(RHO*)Akgr
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * FVB/N

Allelic Composition: RhoTvrm144/Rho+
Genetic Background: involves: C57BL/6J

Allelic Composition: RhoTvrm144/RhoTvrm144
Genetic Background: involves: C57BL/6J

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm1.1Kpal/Rho+,Rpe65450L/Rpe65450M
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rhotm1.1Kpal/Rhotm1.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rhotm2.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0001328 disorganized retinal layers "delaminated or mispositioned sheets of cells comprising the optic part of the retina" [J:33400]
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Allelic Composition: Msh2tm1Mtn/Msh2tm1Mtn
Genetic Background: involves: C57BL/6

 MP:0001999 photosensitivity "alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: RhoTvrm4/Rho+
Genetic Background: B6.Cg-RhoTvrm4/Pjn

Allelic Composition: RhoTvrm1/Rho+
Genetic Background: C57BL/6J-RhoTvrm1

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rhotm1Jlem/Rhotm1Jlem
Genetic Background: involves: 129S4/SvJae

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: RhoR3/Rho+
Genetic Background: C57BL/6J-RhoR3

Allelic Composition: RhoR3/RhoR3
Genetic Background: C57BL/6J-RhoR3

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0003011 delayed dark adaptation "increase in time required for the eye to recover its sensitivity in the dark following exposure to bright lights" [J:68444, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: RhoTvrm4/Rho+
Genetic Background: B6.Cg-RhoTvrm4/Pjn

Allelic Composition: RhoTvrm1/Rho+
Genetic Background: C57BL/6J-RhoTvrm1

 MP:0003099 retinal detachment "detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]
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Allelic Composition: Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rhotm2(RHO/GFP)Jhw/Rhotm2(RHO/GFP)Jhw
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rhotm1.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: RhoTvrm144/Rho+
Genetic Background: involves: C57BL/6J

Allelic Composition: RhoTvrm144/RhoTvrm144
Genetic Background: involves: C57BL/6J

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rhotm2(RHO/GFP)Jhw/Rhotm2(RHO/GFP)Jhw
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: RhoTvrm4/Rho+
Genetic Background: B6.Cg-RhoTvrm4/Pjn

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: B6C3Fe a/a-Dstdt-J/J

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: RhoR3/Rho+
Genetic Background: C57BL/6J-RhoR3

Allelic Composition: RhoR3/RhoR3
Genetic Background: C57BL/6J-RhoR3

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: B6.129S7-Gnai2tm1Lbi

Allelic Composition: Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Rhotm1Phm/Rhotm1Phm
Genetic Background: B6.129S1-Rhotm1Phm

Allelic Composition: Rhotm1.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rhotm1Phm/Rho+,Tg(Rho*G90D*A337V)202Sie/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Rhotm1Phm/Rho+,Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Rhotm2.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rhotm4.1(RHO*/EGFP)Jhw
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

Allelic Composition: RhoTvrm334/Rho+
Genetic Background: B6.Cg-RhoTvrm334/Pjn

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Rhotm1.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rhotm2.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: RhoR3/Rho+
Genetic Background: C57BL/6J-RhoR3

Allelic Composition: RhoR3/RhoR3
Genetic Background: C57BL/6J-RhoR3

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: RhoTvrm4/Rho+
Genetic Background: B6.Cg-RhoTvrm4/Pjn

Allelic Composition: RhoTvrm334/Rho+
Genetic Background: B6.Cg-RhoTvrm334/Pjn

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

Allelic Composition: RhoR3/Rho+
Genetic Background: C57BL/6J-RhoR3

Allelic Composition: RhoR3/RhoR3
Genetic Background: C57BL/6J-RhoR3

Allelic Composition: Rhotm1Phm/Rhotm1Phm
Genetic Background: B6.129S1-Rhotm1Phm

Allelic Composition: Rhotm1Phm/Rho+,Tg(Rho*G90D*A337V)202Sie/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Rhotm1Phm/Rho+,Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Rhotm1Phm/Rhotm1Phm,Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0006068 abnormal horizontal cell morphology "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

Allelic Composition: Rhotm1(EDNRB)Fji/Rhotm1(EDNRB)Fji
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rhotm2(RHO/GFP)Jhw/Rhotm2(RHO/GFP)Jhw
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Rhotm1Jlem/Rho+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: RhoTvrm4/Rho+
Genetic Background: B6.Cg-RhoTvrm4/Pjn

Allelic Composition: RhoTvrm1/Rho+
Genetic Background: C57BL/6J-RhoTvrm1

Allelic Composition: RhoTvrm4/Rho+,Rpe65rd12/Rpe65rd12
Genetic Background: B6.Cg-Rpe65rd12 RhoTvrm4

Allelic Composition: RhoTvrm1/Rho+,Rpe65rd12/Rpe65rd12
Genetic Background: B6.Cg-Rpe65rd12 RhoTvrm1

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm1.1Kpal/Rho+,Rpe65450L/Rpe65450M
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rhotm1Phm/Rhotm1Phm,Tg(Rho*G90D*A337V)202Sie/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Rhotm1Phm/Rhotm1Phm,Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Rhotm2.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Gnat1tm1Clma/Gnat1tm1Clma,Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rhotm4.1(RHO*/EGFP)Jhw
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

Allelic Composition: RhoTvrm334/Rho+
Genetic Background: B6.Cg-RhoTvrm334/Pjn

Allelic Composition: RhoTvrm334/RhoTvrm334
Genetic Background: B6.Cg-RhoTvrm334/Pjn

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
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Allelic Composition: Rhotm1.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm1.1Kpal/Rho+,Rpe65450L/Rpe65450M
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008453 decreased retinal rod cell number "reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
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Allelic Composition: Rhotm2Jlem/Rhotm2Jlem
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Rhotm1.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rhotm1(EDNRB)Fji/Rhotm1(EDNRB)Fji
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rhotm1(EDNRB)Fji/Rho+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Rhotm2Jlem/Rhotm2Jlem
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Rhotm1.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm1.1Kpal/Rho+,Rpe65450L/Rpe65450M
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: RhoTvrm144/Rho+
Genetic Background: involves: C57BL/6J

Allelic Composition: RhoTvrm144/RhoTvrm144
Genetic Background: involves: C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Rhotm1Jlem/Rhotm1Jlem
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Rhotm2Jlem/Rhotm2Jlem
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Rhotm1Phm/Rho+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Rhotm2(RHO/GFP)Jhw/Rhotm2(RHO/GFP)Jhw
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rhotm1.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm1.1Kpal/Rho+,Rpe65450L/Rpe65450M
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rhotm1.1Kpal/Rhotm1.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rhotm1Phm/Rhotm1Phm,Tg(Rho*G90D*A337V)202Sie/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Rhotm1Phm/Rhotm1Phm,Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Rhotm2.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Gnat1tm1Clma/Gnat1tm1Clma,Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Rhotm1.1Eye/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: RhoTvrm144/Rho+
Genetic Background: involves: C57BL/6J

Allelic Composition: RhoTvrm144/RhoTvrm144
Genetic Background: involves: C57BL/6J

 MP:0008516 disorganized retinal outer nuclear layer "derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: RhoTvrm4/Rho+
Genetic Background: B6.Cg-RhoTvrm4/Pjn

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm1Jlem/Rhotm1Jlem
Genetic Background: involves: 129S4/SvJae

Allelic Composition: RhoR3/Rho+
Genetic Background: C57BL/6J-RhoR3

Allelic Composition: RhoR3/Rhotm1Jlem
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: RhoR3/RhoR3
Genetic Background: C57BL/6J-RhoR3

Allelic Composition: RhoTvrm4/Rho+
Genetic Background: B6.Cg-RhoTvrm4/Pjn

Allelic Composition: RhoTvrm4/Rho+,Rpe65rd12/Rpe65rd12
Genetic Background: B6.Cg-Rpe65rd12 RhoTvrm4

Allelic Composition: RhoTvrm1/Rho+,Rpe65rd12/Rpe65rd12
Genetic Background: B6.Cg-Rpe65rd12 RhoTvrm1

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: RhoTvrm144/Rho+
Genetic Background: involves: C57BL/6J

Allelic Composition: RhoTvrm144/RhoTvrm144
Genetic Background: involves: C57BL/6J

 MP:0008581 disorganized photoreceptor inner segment "derangement of the pattern of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: RhoTvrm4/Rho+
Genetic Background: B6.Cg-RhoTvrm4/Pjn

 MP:0008585 absent photoreceptor outer segment "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm1Jlem/Rhotm1Jlem
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: RhoR3/RhoR3
Genetic Background: C57BL/6J-RhoR3

Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Rhotm1Jlem/Rho+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Rhotm1.1(RHO*)Akgr/Rhotm1.1(RHO*)Akgr
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * FVB/N

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm1Phm/Rho+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: RhoTvrm4/Rho+
Genetic Background: B6.Cg-RhoTvrm4/Pjn

Allelic Composition: Rhotm1.1Kpal/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm1Jlem/Rhotm1Jlem
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Rhotm1Phm/Rho+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: RhoR3/Rho+
Genetic Background: C57BL/6J-RhoR3

Allelic Composition: Rhotm1.1Eye/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0011234 abnormal retinol level "any anomaly in the concentration of retinol, which plays an essential role in metabolic functioning of the retina, and growth and differentiation" [ISBN:0-683-40008-8]
Show

Allelic Composition: RhoTvrm4/Rho+
Genetic Background: B6.Cg-RhoTvrm4/Pjn

Allelic Composition: RhoTvrm1/Rho+
Genetic Background: C57BL/6J-RhoTvrm1

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: RhoTvrm334/Rho+
Genetic Background: B6.Cg-RhoTvrm334/Pjn

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Rhotm1.1Eye/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Rhotm1.1Eye/Rho+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: RhoR3/RhoR3
Genetic Background: C57BL/6J-RhoR3

Allelic Composition: RhoTvrm4/Rho+
Genetic Background: B6.Cg-RhoTvrm4/Pjn

Allelic Composition: Rhotm1.1(RHO*)Akgr/Rhotm1.1(RHO*)Akgr
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * FVB/N

Allelic Composition: Rhotm1.1(RHO*)Akgr/Rho+
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052783 Grk4 / O70291 / G protein-coupled receptor kinase 4 / P32298*  / reaction
 ENSMUSG00000003037 Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*  / complex
 ENSMUSG00000022377 Asap1 / Q9QWY8 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 / Q9ULH1* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1*  / complex
 ENSMUSG00000031394 Opn1mw / O35599 / Medium-wave-sensitive opsin 1 / P0DN78* / OPN1LW* / P04000* / P04001* / P0DN77* / OPN1MW2* / OPN1MW3* / opsin 1, long wave sensitive* / opsin 1, medium wave sensitive* / ...  / reaction
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / reaction / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction
 ENSMUSG00000056055 Sag / P20443 / S-antigen, retina and pineal gland (arrestin) / P10523* / S-antigen visual arrestin*  / complex
 ENSMUSG00000037098 Q8CHD8 / Rab11fip3 / Rab11 family-interacting protein 3 / O75154*  / complex / reaction
 ENSMUSG00000004771 P62492 / Rab11a / RAB11A, member RAS oncogene family / P62491*  / complex / reaction
 ENSMUSG00000009108 Gnat2 / P50149 / guanine nucleotide binding protein, alpha transducing 2 / P19087* / G protein subunit alpha transducin 2*  / reaction / complex
 ENSMUSG00000021877 Arf4 / P61750 / ADP-ribosylation factor 4 / P18085*  / complex / reaction
 ENSMUSG00000058831 Opn1sw / P51491 / Short-wave-sensitive opsin 1 / P03999* / opsin 1, short wave sensitive*  / reaction
 ENSMUSG00000034837 Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*  / complex / reaction
 ENSMUSG00000030324 Rho / P15409 / Rhodopsin / P08100*  / reaction
 ENSMUSG00000031450 Grk1 / G protein-coupled receptor kinase 1 / Q15835*  / reaction
 ENSMUSG00000062168 Ppef1 / O35655 / Serine/threonine-protein phosphatase with EF-hands 1 / O14829* / protein phosphatase with EF-hand domain 1*  / reaction






 

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