ENSMUSG00000021799


Mus musculus

Features
Gene ID: ENSMUSG00000021799
  
Biological name :Opn4
  
Synonyms : Melanopsin / Opn4 / Q9QXZ9
  
Possible biological names infered from orthology : opsin 4 / Q9UHM6
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 34590618
Gene end: 34600142
  
Corresponding Affymetrix probe sets: 10418971 (MoGene1.0st)   1421584_at (Mouse Genome 430 2.0 Array)   1445121_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022331
Ensembl peptide - ENSMUSP00000126136
NCBI entrez gene - 30044     See in Manteia.
MGI - MGI:1353425
RefSeq - NM_001128599
RefSeq - NM_013887
RefSeq Peptide - NP_001122071
RefSeq Peptide - NP_038915
swissprot - Q9QXZ9
Ensembl - ENSMUSG00000021799
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 opn4.1ENSDARG00000007553Danio rerio
 opn4aENSDARG00000022098Danio rerio
 opn4bENSDARG00000053929Danio rerio
 OPN4ENSGALG00000001934Gallus gallus
 OPN4ENSG00000122375Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Opn1sw / P51491 / Short-wave-sensitive opsin 1 / P03999* / opsin 1, short wave sensitive*ENSMUSG0000005883119
Rrh / O35214 / retinal pigment epithelium derived rhodopsin homolog / O14718*ENSMUSG0000002801219
Opn1mw / O35599 / Medium-wave-sensitive opsin 1 / P0DN78* / OPN1LW* / P04000* / P04001* / P0DN77* / OPN1MW2* / OPN1MW3* / opsin 1, long wave sensitive* / opsin 1, medium wave sensitive* / ...ENSMUSG0000003139418
Rho / P15409 / Rhodopsin / P08100*ENSMUSG0000003032418
Opn3 / Q9WUK7 / Opsin-3 / Q9H1Y3*ENSMUSG0000002652517
Opn5 / Q6VZZ7 / Opsin-5 / Q6U736*ENSMUSG0000004397216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001760  Opsin
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR027430  Visual pigments (opsins) retinal binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0007602 phototransduction ISO
 biological_processGO:0016056 rhodopsin mediated signaling pathway IDA
 biological_processGO:0018298 protein-chromophore linkage IEA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050896 response to stimulus IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005502 11-cis retinal binding IEA
 molecular_functionGO:0008020 G-protein coupled photoreceptor activity IEA
 molecular_functionGO:0009881 photoreceptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
Opsins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001999 photosensitivity "alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria1tm5Rlh/Gria1tm5Rlh
Genetic Background: involves: 129 * C57BL/6

 MP:0002003 meiotic pupils "charcterized by contraction of the pupils " [J:17194]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: B6NCrl.Cg-Cplx2tm1Rmnd

Allelic Composition: Opn4tm2.1(cre/ERT2)Saha/Opn4+,Pou4f2tm2.1Nat/Pou4f2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm4Whk/Pou4f2+,Tg(CAG-Bgeo/ALPP)1Lbe/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4tm1Yau,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002638 abnormal pupillary reflex "alterations or failure of the pupil to change in diamater as a reflex response to any stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Opn4tm1Skay/Opn4tm1Skay
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Opn4tm1Skay/Opn4tm1Skay,Pde6brd1/Pde6brd1
Genetic Background: B6.Cg-Pde6brd1 Opn4tm1Skay

 MP:0006156 abnormal visual pursuit "anomaly in the ability to selectively track a moving object" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0006243 abnormal pupil dilation reaction to light "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Opn4tm2(DTA)Yau/Opn4+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129S * C57BL/6

Allelic Composition: Opn4tm1Skay/Opn4tm1Skay,Pde6brd1/Pde6brd1
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129S * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm4Whk/Pou4f2+,Tg(CAG-Bgeo/ALPP)1Lbe/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4tm1Yau,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Opn4tm2(DTA)Yau/Opn4+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Opn4tm1Skay/Opn4tm1Skay
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Dscamtm1Pfu/Dscamtm1Pfu,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129 * C57BL/6

 MP:0008847 abnormal suprachiasmatic nucleus morphology "any structural anomaly of an ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the optic chiasm; it receives input from the retina and influences neuroendocrine function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.317.357.342.625]
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129S * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm2.1Nat/Pou4f2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Opn4tm2.1(cre/ERT2)Saha/Opn4+,Pou4f2tm2.1Nat/Pou4f2+
Genetic Background: involves: 129 * C57BL/6

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dscamtm1Pfu/Dscamtm1Pfu,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129 * C57BL/6

 MP:0009639 abnormal olivary pretectal nucleus morphology "any strucural anomaly of one of several pretectal nuclei with direct input from the eye and the only one containing neurons whose rate of firing is linearly related to the intensity of light falling on the retina" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm4Whk/Pou4f2+,Tg(CAG-Bgeo/ALPP)1Lbe/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4tm1Yau,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011831 abnormal visual contrast sensitivity "any abnormality in the ability to distinguish between increments of light versus dark" [MGI:smb]
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Allelic Composition: LexmRetro/Lexm+
Genetic Background: involves: C57BL/6J

 MP:0020468 abnormal circadian behavior period "any change in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Opn4tm1.1(cre)Saha/Opn4+,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0020469 prolonged circadian behavior period "increase in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Opn4tm1Skay/Opn4tm1Skay
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Opn4tm2(DTA)Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Opn4tm1Skay/Opn4tm1Skay
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Opn4tm2(DTA)Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129S * C57BL/6

Allelic Composition: Opn4tm1Skay/Opn4tm1Skay,Pde6brd1/Pde6brd1
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0020477 abnormal locomotor circadian rhythm "any anomaly in the rhythm of the locomotor activity of an organism during its 24 hour activity cycle" [GO:0045475]
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Allelic Composition: Opn4tm2(DTA)Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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