ENSMUSG00000004771


Mus musculus

Features
Gene ID: ENSMUSG00000004771
  
Biological name :Rab11a
  
Synonyms : P62492 / Rab11a / RAB11A, member RAS oncogene family
  
Possible biological names infered from orthology : P62491
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: C
Gene start: 64715299
Gene end: 64737758
  
Corresponding Affymetrix probe sets: 10594480 (MoGene1.0st)   1434549_at (Mouse Genome 430 2.0 Array)   1449256_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127968
Ensembl peptide - ENSMUSP00000129729
Ensembl peptide - ENSMUSP00000129163
Ensembl peptide - ENSMUSP00000128150
Ensembl peptide - ENSMUSP00000004892
Ensembl peptide - ENSMUSP00000125755
NCBI entrez gene - 53869     See in Manteia.
MGI - MGI:1858202
RefSeq - NM_017382
RefSeq Peptide - NP_059078
swissprot - F6R2Z5
swissprot - F8WGS1
swissprot - P62492
swissprot - E9Q6B3
swissprot - Q0PD45
swissprot - E9Q3P9
swissprot - E9PZB2
Ensembl - ENSMUSG00000004771
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5ZJN2ENSGALG00000007615Gallus gallus
 P62491ENSG00000103769Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P46638 / Rab11b / RAB11B, member RAS oncogene family / Q15907*ENSMUSG0000007745090
Rab25 / Q9WTL2 / RAB25, member RAS oncogene family / P57735*ENSMUSG0000000860161
Rab2b / P59279 / RAB2B, member RAS oncogene family / Q8WUD1*ENSMUSG0000002215945
Rab2a / P53994 / Ras-related protein Rab-2A / P61019* / RAB2A, member RAS oncogene family*ENSMUSG0000004718744
Rab14 / Q91V41 / RAB14, member RAS oncogene family / P61106*ENSMUSG0000002687843
Rab4a / P56371 / Ras-related protein Rab-4A / P20338* / RAB4A, member RAS oncogene family*ENSMUSG0000001947843
Rab4b / Q91ZR1 / RAB4B, member RAS oncogene family / P61018* / RAB4B-EGLN2* / RAB4B-EGLN2 readthrough (NMD candidate)*ENSMUSG0000005329143
Q8BHC1 / Rab39b / RAB39B, member RAS oncogene family / Q96DA2*ENSMUSG0000003120240
Rab39 / Q8BHD0 / RAB39, member RAS oncogene family / Q14964* / RAB39A* / RAB39A, member RAS oncogene family*ENSMUSG0000005506938
Rab18 / P35293 / RAB18, member RAS oncogene family / Q9NP72*ENSMUSG0000007363938
Rab42 / Q0PD08 / Ras-related protein Rab-42 / Q8N4Z0* / RAB42, member RAS oncogene family*ENSMUSG0000008968732


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007080 mitotic metaphase plate congression IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010796 regulation of multivesicular body size IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030953 astral microtubule organization IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032402 melanosome transport IMP
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0036258 multivesicular body assembly IEA
 biological_processGO:0045773 positive regulation of axon extension IMP
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0051223 regulation of protein transport IEA
 biological_processGO:0051650 establishment of vesicle localization IEA
 biological_processGO:0060627 regulation of vesicle-mediated transport IEA
 biological_processGO:0072594 establishment of protein localization to organelle IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090150 establishment of protein localization to membrane IEA
 biological_processGO:0090307 mitotic spindle assembly IEA
 biological_processGO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1990182 exosomal secretion IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005828 kinetochore microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032154 cleavage furrow ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045335 phagocytic vesicle ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:0098837 postsynaptic recycling endosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0031489 myosin V binding IEA


Pathways (from Reactome)
Pathway description
Vasopressin regulates renal water homeostasis via Aquaporins
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
TBC/RABGAPs
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

Allelic Composition: Rab11atm1.1Ngao/Rab11atm1.1Ngao,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0008142 decreased small intestinal villus size "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

Allelic Composition: Rab11atm1.1Ngao/Rab11atm1.1Ngao,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

Allelic Composition: Rab11atm1.1Ngao/Rab11atm1.1Ngao,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Orl

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003037 Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*  / complex / reaction
 ENSMUSG00000040022 G3XA57 / Rab11fip2 / RAB11 family interacting protein 2 (class I) / Q7L804* / RAB11 family interacting protein 2*  / complex
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / complex / reaction
 ENSMUSG00000025885 Myo5b / myosin VB / Q9ULV0*  / complex
 ENSMUSG00000005864 Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*  / complex / reaction
 ENSMUSG00000022377 Asap1 / Q9QWY8 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 / Q9ULH1* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1*  / complex / reaction
 ENSMUSG00000021877 Arf4 / P61750 / ADP-ribosylation factor 4 / P18085*  / complex / reaction
 ENSMUSG00000030897 Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*  / reaction / complex
 ENSMUSG00000030324 Rho / P15409 / Rhodopsin / P08100*  / complex / reaction
 ENSMUSG00000032855 Pkd1 / O08852 / Polycystin-1 / P98161* / polycystin 1, transient receptor potential channel interacting*  / complex / reaction
 ENSMUSG00000027378 Nphp1 / nephronophthisis 1 (juvenile) homolog (human) / O15259* / nephrocystin 1*  / complex
 ENSMUSG00000039577 Nphp4 / P59240 / Mus musculus nephronophthisis 4 (juvenile) homolog (human) (Nphp4), transcript variant 2, mRNA. / O75161* / nephrocystin 4*  / complex
 ENSMUSG00000033282 Q8CG73 / Rpgrip1l / Rpgrip1-like / Q68CZ1*  / complex
 ENSMUSG00000037098 Q8CHD8 / Rab11fip3 / Rab11 family-interacting protein 3 / O75154*  / complex / reaction






 

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