ENSMUSG00000019478


Mus musculus

Features
Gene ID: ENSMUSG00000019478
  
Biological name :Rab4a
  
Synonyms : P56371 / Rab4a / Ras-related protein Rab-4A
  
Possible biological names infered from orthology : P20338 / RAB4A, member RAS oncogene family
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E2
Gene start: 123805985
Gene end: 123835287
  
Corresponding Affymetrix probe sets: 10576391 (MoGene1.0st)   1418341_at (Mouse Genome 430 2.0 Array)   1449048_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148777
Ensembl peptide - ENSMUSP00000113401
Ensembl peptide - ENSMUSP00000113886
NCBI entrez gene - 19341     See in Manteia.
MGI - MGI:105069
RefSeq - NM_009003
RefSeq - XM_006530773
RefSeq Peptide - NP_033029
swissprot - A0A1D5RMH1
swissprot - P56371
Ensembl - ENSMUSG00000019478
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab4aENSDARG00000019144Danio rerio
 RAB4AENSGALG00000036218Gallus gallus
 RAB4AENSG00000168118Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab4b / Q91ZR1 / RAB4B, member RAS oncogene family / P61018* / RAB4B-EGLN2* / RAB4B-EGLN2 readthrough (NMD candidate)*ENSMUSG0000005329184
Rab14 / Q91V41 / RAB14, member RAS oncogene family / P61106*ENSMUSG0000002687858
Rab2a / P53994 / Ras-related protein Rab-2A / P61019* / RAB2A, member RAS oncogene family*ENSMUSG0000004718751
Rab2b / P59279 / RAB2B, member RAS oncogene family / Q8WUD1*ENSMUSG0000002215950
P46638 / Rab11b / RAB11B, member RAS oncogene family / Q15907*ENSMUSG0000007745043
P62492 / Rab11a / RAB11A, member RAS oncogene family / P62491*ENSMUSG0000000477142
Rab25 / Q9WTL2 / RAB25, member RAS oncogene family / P57735*ENSMUSG0000000860140
Rab39 / Q8BHD0 / RAB39, member RAS oncogene family / Q14964* / RAB39A* / RAB39A, member RAS oncogene family*ENSMUSG0000005506939
Q8BHC1 / Rab39b / RAB39B, member RAS oncogene family / Q96DA2*ENSMUSG0000003120237
Rab18 / P35293 / RAB18, member RAS oncogene family / Q9NP72*ENSMUSG0000007363937
Rab42 / Q0PD08 / Ras-related protein Rab-42 / Q8N4Z0* / RAB42, member RAS oncogene family*ENSMUSG0000008968732


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IDA
 biological_processGO:0019882 antigen processing and presentation ISO
 biological_processGO:0030100 regulation of endocytosis IDA
 biological_processGO:0032482 Rab protein signal transduction IEA
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031982 vesicle ISO
 cellular_componentGO:0032593 insulin-responsive compartment IBA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0055037 recycling endosome ISO
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome ISO
 cellular_componentGO:0098837 postsynaptic recycling endosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001671 ATPase activator activity IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008565 protein transporter activity IDA
 molecular_functionGO:0019003 GDP binding ISO
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
TBC/RABGAPs
RAB geranylgeranylation
MET receptor recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017831 Rab5a / Q9CQD1 / Ras-related protein Rab-5A / P20339* / RAB5A, member RAS oncogene family*  / complex / reaction
 ENSMUSG00000020375 Rufy1 / Q8BIJ7 / RUN and FYVE domain-containing protein 1 / Q96T51* / RUN and FYVE domain containing 1*  / reaction / complex
 ENSMUSG00000027475 Kif3b / Q61771 / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed / O15066* / kinesin family member 3B*  / reaction / complex
 ENSMUSG00000026878 Rab14 / Q91V41 / RAB14, member RAS oncogene family / P61106*  / reaction / complex
 ENSMUSG00000018395 Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*  / complex / reaction
 ENSMUSG00000026585 Kifap3 / P70188 / Kinesin-associated protein 3 / Q92845*  / complex / reaction






 

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