Homo sapiens

Gene ID: ENSG00000168118
Biological name :RAB4A
Synonyms : P20338 / RAB4A / RAB4A, member RAS oncogene family
Possible biological names infered from orthology :
Species: Homo sapiens
Chr. number: 1
Strand: 1
Band: q42.13
Gene start: 229271062
Gene end: 229305894
Corresponding Affymetrix probe sets: 203581_at (Human Genome U133 Plus 2.0 Array)   203582_s_at (Human Genome U133 Plus 2.0 Array)   206272_at (Human Genome U133 Plus 2.0 Array)   
Cross references: Ensembl peptide - ENSP00000355651
Ensembl peptide - ENSP00000482077
NCBI entrez gene - 5867     See in Manteia.
OMIM - 179511
RefSeq - NM_004578
RefSeq - NM_001271998
RefSeq Peptide - NP_001258927
RefSeq Peptide - NP_004569
swissprot - P20338
swissprot - A0A087WYT5
swissprot - A0A024R3U9
Ensembl - ENSG00000168118
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab4aENSDARG00000019144Danio rerio
 RAB4AENSGALG00000036218Gallus gallus
 Rab4aENSMUSG00000019478Mus musculus

Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB4B-EGLN2 / RAB4B-EGLN2 readthrough (NMD candidate)ENSG0000017157085
RAB4B / P61018 / RAB4B, member RAS oncogene familyENSG0000016757885
RAB14 / P61106 / RAB14, member RAS oncogene familyENSG0000011939658
RAB2B / Q8WUD1 / RAB2B, member RAS oncogene familyENSG0000012947251
RAB2A / P61019 / RAB2A, member RAS oncogene familyENSG0000010438851
Q15907 / RAB11B / RAB11B, member RAS oncogene familyENSG0000018523644
P62491 / RAB11A / RAB11A, member RAS oncogene familyENSG0000010376942
RAB25 / P57735 / RAB25, member RAS oncogene familyENSG0000013269840
Q14964 / RAB39A / RAB39A, member RAS oncogene familyENSG0000017933139
RAB18 / Q9NP72 / RAB18, member RAS oncogene familyENSG0000009924637
Q96DA2 / RAB39B / RAB39B, member RAS oncogene familyENSG0000015596137
RAB42 / Q8N4Z0 / RAB42, member RAS oncogene familyENSG0000018806012

Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0019882 antigen processing and presentation IMP
 biological_processGO:0030100 regulation of endocytosis IBA
 biological_processGO:0032482 Rab protein signal transduction IEA
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0032593 insulin-responsive compartment IBA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome IDA
 cellular_componentGO:0098837 postsynaptic recycling endosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001671 ATPase activator activity IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008565 protein transporter activity IEA
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0051117 ATPase binding IEA

Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Synthesis of PIPs at the plasma membrane
RAB geranylgeranylation
MET receptor recycling

Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match

Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000075945 KIFAP3 / Q92845 / kinesin associated protein 3  / complex / reaction
 ENSG00000176783 RUFY1 / Q96T51 / RUN and FYVE domain containing 1  / reaction / complex
 ENSG00000144566 RAB5A / P20339 / RAB5A, member RAS oncogene family  / reaction / complex
 ENSG00000119396 RAB14 / P61106 / RAB14, member RAS oncogene family  / reaction / complex
 ENSG00000101350 KIF3B / O15066 / kinesin family member 3B  / reaction / complex
 ENSG00000131437 KIF3A / Q9Y496 / kinesin family member 3A  / reaction / complex


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