ENSG00000168118


Homo sapiens

Features
Gene ID: ENSG00000168118
  
Biological name :RAB4A
  
Synonyms : P20338 / RAB4A / RAB4A, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q42.13
Gene start: 229271062
Gene end: 229305894
  
Corresponding Affymetrix probe sets: 203581_at (Human Genome U133 Plus 2.0 Array)   203582_s_at (Human Genome U133 Plus 2.0 Array)   206272_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355651
Ensembl peptide - ENSP00000482077
NCBI entrez gene - 5867     See in Manteia.
OMIM - 179511
RefSeq - NM_004578
RefSeq - NM_001271998
RefSeq Peptide - NP_001258927
RefSeq Peptide - NP_004569
swissprot - P20338
swissprot - A0A087WYT5
swissprot - A0A024R3U9
Ensembl - ENSG00000168118
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab4aENSDARG00000019144Danio rerio
 RAB4AENSGALG00000036218Gallus gallus
 Rab4aENSMUSG00000019478Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB4B-EGLN2 / RAB4B-EGLN2 readthrough (NMD candidate)ENSG0000017157085
RAB4B / P61018 / RAB4B, member RAS oncogene familyENSG0000016757885
RAB14 / P61106 / RAB14, member RAS oncogene familyENSG0000011939658
RAB2B / Q8WUD1 / RAB2B, member RAS oncogene familyENSG0000012947251
RAB2A / P61019 / RAB2A, member RAS oncogene familyENSG0000010438851
Q15907 / RAB11B / RAB11B, member RAS oncogene familyENSG0000018523644
P62491 / RAB11A / RAB11A, member RAS oncogene familyENSG0000010376942
RAB25 / P57735 / RAB25, member RAS oncogene familyENSG0000013269840
Q14964 / RAB39A / RAB39A, member RAS oncogene familyENSG0000017933139
RAB18 / Q9NP72 / RAB18, member RAS oncogene familyENSG0000009924637
Q96DA2 / RAB39B / RAB39B, member RAS oncogene familyENSG0000015596137
RAB42 / Q8N4Z0 / RAB42, member RAS oncogene familyENSG0000018806012


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0019882 antigen processing and presentation IMP
 biological_processGO:0030100 regulation of endocytosis IBA
 biological_processGO:0032482 Rab protein signal transduction IEA
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0032593 insulin-responsive compartment IBA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome IDA
 cellular_componentGO:0098837 postsynaptic recycling endosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001671 ATPase activator activity IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008565 protein transporter activity IEA
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Synthesis of PIPs at the plasma membrane
TBC/RABGAPs
RAB geranylgeranylation
MET receptor recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000075945 KIFAP3 / Q92845 / kinesin associated protein 3  / complex / reaction
 ENSG00000176783 RUFY1 / Q96T51 / RUN and FYVE domain containing 1  / reaction / complex
 ENSG00000144566 RAB5A / P20339 / RAB5A, member RAS oncogene family  / reaction / complex
 ENSG00000119396 RAB14 / P61106 / RAB14, member RAS oncogene family  / reaction / complex
 ENSG00000101350 KIF3B / O15066 / kinesin family member 3B  / reaction / complex
 ENSG00000131437 KIF3A / Q9Y496 / kinesin family member 3A  / reaction / complex






 

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