ENSG00000176783


Homo sapiens

Features
Gene ID: ENSG00000176783
  
Biological name :RUFY1
  
Synonyms : Q96T51 / RUFY1 / RUN and FYVE domain containing 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.3
Gene start: 179550558
Gene end: 179610026
  
Corresponding Affymetrix probe sets: 218243_at (Human Genome U133 Plus 2.0 Array)   229179_at (Human Genome U133 Plus 2.0 Array)   233380_s_at (Human Genome U133 Plus 2.0 Array)   233381_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426701
Ensembl peptide - ENSP00000425533
Ensembl peptide - ENSP00000426117
Ensembl peptide - ENSP00000325594
Ensembl peptide - ENSP00000377087
Ensembl peptide - ENSP00000377094
Ensembl peptide - ENSP00000390025
NCBI entrez gene - 80230     See in Manteia.
OMIM - 610327
RefSeq - XM_017009895
RefSeq - NM_025158
RefSeq - XM_005265993
RefSeq - XM_006714921
RefSeq - XM_006714922
RefSeq - XM_017009891
RefSeq - XM_017009892
RefSeq - XM_017009893
RefSeq - XM_017009894
RefSeq - NM_001040451
RefSeq - NM_001040452
RefSeq Peptide - NP_079434
RefSeq Peptide - NP_001035541
RefSeq Peptide - NP_001035542
swissprot - H0YA47
swissprot - H0Y9Y8
swissprot - Q96T51
swissprot - H0YAC8
swissprot - J3KPP6
Ensembl - ENSG00000176783
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rufy1ENSDARG00000078685Danio rerio
 RUFY1ENSGALG00000029706Gallus gallus
 Rufy1ENSMUSG00000020375Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RUFY2 / Q8WXA3 / RUN and FYVE domain containing 2ENSG0000020413054
RUFY3 / Q7L099 / RUN and FYVE domain containing 3ENSG0000001818944
Q96NL0 / RUNDC3B / RUN domain containing 3BENSG0000010578416
Q59EK9 / RUNDC3A / RUN domain containing 3AENSG0000010830915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR001841  Zinc finger, RING-type
 IPR004012  RUN domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related
 IPR037213  RUN domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030100 regulation of endocytosis IPI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008565 protein transporter activity IEA
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0042169 SH2 domain binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000144566 RAB5A / P20339 / RAB5A, member RAS oncogene family  / reaction / complex
 ENSG00000102010 BMX / P51813 / BMX non-receptor tyrosine kinase  / reaction
 ENSG00000168118 RAB4A / P20338 / RAB4A, member RAS oncogene family  / complex / reaction
 ENSG00000119396 RAB14 / P61106 / RAB14, member RAS oncogene family  / complex / reaction






 

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