ENSG00000144566


Homo sapiens

Features
Gene ID: ENSG00000144566
  
Biological name :RAB5A
  
Synonyms : P20339 / RAB5A / RAB5A, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p24.3
Gene start: 19947079
Gene end: 19985175
  
Corresponding Affymetrix probe sets: 206113_s_at (Human Genome U133 Plus 2.0 Array)   209089_at (Human Genome U133 Plus 2.0 Array)   240990_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398450
Ensembl peptide - ENSP00000411941
Ensembl peptide - ENSP00000403533
Ensembl peptide - ENSP00000273047
Ensembl peptide - ENSP00000396632
NCBI entrez gene - 5868     See in Manteia.
OMIM - 179512
RefSeq - NM_004162
RefSeq - NM_001292048
RefSeq Peptide - NP_001278977
RefSeq Peptide - NP_004153
swissprot - C9J3X8
swissprot - P20339
swissprot - A0A024R2K1
swissprot - F8WCY6
swissprot - F8WD79
Ensembl - ENSG00000144566
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAB5AENSGALG00000011272Gallus gallus
 Rab5aENSMUSG00000017831Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB5C / P51148 / RAB5C, member RAS oncogene familyENSG0000010877487
RAB5B / P61020 / RAB5B, member RAS oncogene familyENSG0000011154082
AC099811.2ENSG0000026726167
Q9UL26 / RAB22A / RAB22A, member RAS oncogene familyENSG0000012420944
RAB17 / Q9H0T7 / RAB17, member RAS oncogene familyENSG0000012483943
RAB31 / Q13636 / RAB31, member RAS oncogene familyENSG0000016846143
RAB21 / Q9UL25 / RAB21, member RAS oncogene familyENSG0000008037140
RAB20 / Q9NX57 / RAB20, member RAS oncogene familyENSG0000013983232
Q9NZQ0 / DNAJC27 / DnaJ heat shock protein family (Hsp40) member C27ENSG0000011513726


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0006897 endocytosis TAS
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030100 regulation of endocytosis IBA
 biological_processGO:0036465 synaptic vesicle recycling IDA
 biological_processGO:0039694 viral RNA genome replication IMP
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045022 early endosome to late endosome transport IMP
 biological_processGO:0045056 transcytosis IMP
 biological_processGO:0045921 positive regulation of exocytosis IMP
 biological_processGO:0051036 regulation of endosome size IMP
 biological_processGO:0051489 regulation of filopodium assembly IDA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:2000286 receptor internalization involved in canonical Wnt signaling pathway IMP
 biological_processGO:2000300 regulation of synaptic vesicle exocytosis IMP
 biological_processGO:2000785 regulation of autophagosome assembly TAS
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008021 synaptic vesicle ISS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IBA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030665 clathrin-coated vesicle membrane TAS
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0036477 somatodendritic compartment IDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043195 terminal bouton IDA
 cellular_componentGO:0043679 axon terminus ISS
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098559 cytoplasmic side of early endosome membrane IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IDA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0019003 GDP binding IDA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
TBC/RABGAPs
Clathrin-mediated endocytosis
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131381 RBSN / Q9H1K0 / rabenosyn, RAB effector  / complex / reaction
 ENSG00000165219 GAPVD1 / Q14C86 / GTPase activating protein and VPS9 domains 1  / complex
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex
 ENSG00000136631 VPS45 / Q9NRW7 / vacuolar protein sorting 45 homolog  / reaction / complex
 ENSG00000154710 Q9UJ41 / RABGEF1 / RAB guanine nucleotide exchange factor 1  / complex
 ENSG00000103365 GGA2 / Q9UJY4 / golgi associated, gamma adaptin ear containing, ARF binding protein 2  / complex
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex
 ENSG00000125447 GGA3 / Q9NZ52 / golgi associated, gamma adaptin ear containing, ARF binding protein 3  / complex
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000100083 GGA1 / Q9UJY5 / golgi associated, gamma adaptin ear containing, ARF binding protein 1  / complex
 ENSG00000274611 Q8IZP1 / TBC1D3 / TBC1 domain family member 3  / reaction / complex
 ENSG00000176783 RUFY1 / Q96T51 / RUN and FYVE domain containing 1  / complex / reaction
 ENSG00000029725 Q15276 / RABEP1 / rabaptin, RAB GTPase binding effector protein 1  / complex
 ENSG00000168118 RAB4A / P20338 / RAB4A, member RAS oncogene family  / complex / reaction
 ENSG00000119396 RAB14 / P61106 / RAB14, member RAS oncogene family  / reaction / complex






 

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