ENSGALG00000011272


Gallus gallus

Features
Gene ID: ENSGALG00000011272
  
Biological name :RAB5A
  
Synonyms : RAB5A / RAB5A, member RAS oncogene family
  
Possible biological names infered from orthology : P20339 / Q9CQD1 / Ras-related protein Rab-5A
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 35958094
Gene end: 35975037
  
Corresponding Affymetrix probe sets: GgaAffx.12840.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018371
Ensembl peptide - ENSGALP00000062187
NCBI entrez gene - 420649     See in Manteia.
RefSeq - NM_001006363
RefSeq - XM_015281490
RefSeq Peptide - NP_001006363
swissprot - Q5ZIP7
Ensembl - ENSGALG00000011272
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab5aaENSDARG00000018602Danio rerio
 rab5abENSDARG00000007257Danio rerio
 RAB5AENSG00000144566Homo sapiens
 Rab5aENSMUSG00000017831Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB5C / Q98932 / Ras-related protein Rab-5C / P51148* / P35278* / RAB5C, member RAS oncogene family*ENSGALG0000000335988
RAB5B / ras-related protein Rab-5B / P61020* / P61021* / RAB5B, member RAS oncogene family*ENSGALG0000004248273
RAB17 / RAB17, member RAS oncogene family / P35292* / Q9H0T7* / Ras-related protein Rab-17 *ENSGALG0000000389945
RAB22A / RAB22A, member RAS oncogene family / P35285* / Q9UL26*ENSGALG0000000755444
RAB31 / RAB31, member RAS oncogene family / Q13636*ENSGALG0000002287443
RAB21 / RAB21, member RAS oncogene family / P35282* / Q9UL25*ENSGALG0000001018341
RAB20 / RAB20, member RAS oncogene family / P35295* / Q9NX57* / Ras-related protein Rab-20 *ENSGALG0000001684431
Q6IMM1 / DNAJC27 / DnaJ homolog subfamily C member 27 / Q8CFP6* / Q9NZQ0* / DnaJ heat shock protein family (Hsp40) member C27*ENSGALG0000002896727


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0030100 regulation of endocytosis IBA
 biological_processGO:0036465 synaptic vesicle recycling IEA
 biological_processGO:0039694 viral RNA genome replication IEA
 biological_processGO:0045022 early endosome to late endosome transport IEA
 biological_processGO:0045056 transcytosis IEA
 biological_processGO:0045921 positive regulation of exocytosis IEA
 biological_processGO:0051036 regulation of endosome size IEA
 biological_processGO:0051489 regulation of filopodium assembly IBA
 biological_processGO:2000286 receptor internalization involved in canonical Wnt signaling pathway IEA
 biological_processGO:2000300 regulation of synaptic vesicle exocytosis IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030139 endocytic vesicle IBA
 cellular_componentGO:0036477 somatodendritic compartment IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0098559 cytoplasmic side of early endosome membrane IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0019003 GDP binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
TBC/RABGAPs
Clathrin-mediated endocytosis
RAB GEFs exchange GTP for GDP on RABs
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000993 GAPVD1 / GTPase activating protein and VPS9 domains 1 / Q14C86* / Q6PAR5* / GTPase-activating protein and VPS9 domain-containing protein 1 *  / complex
 ENSGALG00000008500 RBSN / rabenosyn, RAB effector / Q80Y56* / Q9H1K0* / Rabenosyn-5 *  / complex / reaction
 ENSGALG00000001474 RAB14 / Q5ZKU5 / Ras-related protein Rab-14 / Q91V41* / P61106* / RAB14, member RAS oncogene family*  / complex / reaction
 ENSGALG00000039658 GGA1 / golgi associated, gamma adaptin ear containing, ARF binding protein 1 / Q8R0H9* / Q9UJY5* / ADP-ribosylation factor-binding protein GGA1 *  / complex
 ENSGALG00000036218 RAB4A / RAB4A, member RAS oncogene family / P20338* / P56371* / Ras-related protein Rab-4A *  / complex / reaction
 ENSGALG00000021611 Q9JM13* / Q9UJ41* / RABGEF1* / AC027644.4* / Rab5 GDP/GTP exchange factor * / RAB guanine nucleotide exchange factor 1*  / complex
 ENSGALG00000006140 GGA2 / golgi associated, gamma adaptin ear containing, ARF binding protein 2 / Q6P5E6* / Q9UJY4* / ADP-ribosylation factor-binding protein GGA2 *  / complex
 ENSGALG00000039221 A6NDS4* / B9A6J9* / TBC1D3* / P0C7X1* / Q2M2D7* / Q6DHY5* / Q6IPX1* / Q8IZP1* / Q86UD7* / TBC1D3F* / TBC1D3H* / TBC1D3G* / TBC1D3I* / TBC1D3K* / TBC1D3L* / TBC1D26* / TBC1D28* / TBC1D3B* / ...  / reaction / complex






 

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