ENSMUSG00000017831


Mus musculus

Features
Gene ID: ENSMUSG00000017831
  
Biological name :Rab5a
  
Synonyms : Q9CQD1 / Rab5a / Ras-related protein Rab-5A
  
Possible biological names infered from orthology : P20339 / RAB5A, member RAS oncogene family
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: C
Gene start: 53479234
Gene end: 53507671
  
Corresponding Affymetrix probe sets: 10445898 (MoGene1.0st)   1416426_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017975
NCBI entrez gene - 271457     See in Manteia.
MGI - MGI:105926
RefSeq - NM_025887
RefSeq Peptide - NP_080163
swissprot - Q9CQD1
Ensembl - ENSMUSG00000017831
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab5aaENSDARG00000018602Danio rerio
 rab5abENSDARG00000007257Danio rerio
 RAB5AENSGALG00000011272Gallus gallus
 RAB5AENSG00000144566Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab5c / P35278 / RAB5C, member RAS oncogene family / P51148*ENSMUSG0000001917388
Rab5b / P61021 / RAB5B, member RAS oncogene family / P61020*ENSMUSG0000000071182
Rab31 / RAB31, member RAS oncogene family / Q13636*ENSMUSG0000005651544
P35285 / Rab22a / RAB22A, member RAS oncogene family / Q9UL26*ENSMUSG0000002751943
Rab21 / P35282 / RAB21, member RAS oncogene family / Q9UL25*ENSMUSG0000002013241
Rab17 / P35292 / Ras-related protein Rab-17 / Q9H0T7* / RAB17, member RAS oncogene family*ENSMUSG0000002630441
Rab20 / P35295 / Ras-related protein Rab-20 / Q9NX57* / RAB20, member RAS oncogene family*ENSMUSG0000003150430
Q8CFP6 / Dnajc27 / DnaJ homolog subfamily C member 27 / Q9NZQ0* / DnaJ heat shock protein family (Hsp40) member C27*ENSMUSG0000002065727


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis ISO
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030100 regulation of endocytosis IBA
 biological_processGO:0036465 synaptic vesicle recycling IEA
 biological_processGO:0039694 viral RNA genome replication IEA
 biological_processGO:0045022 early endosome to late endosome transport IEA
 biological_processGO:0045056 transcytosis IEA
 biological_processGO:0045921 positive regulation of exocytosis IEA
 biological_processGO:0051036 regulation of endosome size IEA
 biological_processGO:0051489 regulation of filopodium assembly IEA
 biological_processGO:2000286 receptor internalization involved in canonical Wnt signaling pathway IEA
 biological_processGO:2000300 regulation of synaptic vesicle exocytosis IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0008021 synaptic vesicle ISS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0036477 somatodendritic compartment IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043679 axon terminus ISS
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0098559 cytoplasmic side of early endosome membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0019001 guanyl nucleotide binding IDA
 molecular_functionGO:0019003 GDP binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Clathrin-mediated endocytosis
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0003898 abnormal QRS complex "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015747 Vps45 / P97390 / vacuolar protein sorting 45 / Q9NRW7* / vacuolar protein sorting 45 homolog*  / complex / reaction
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / complex
 ENSMUSG00000026878 Rab14 / Q91V41 / RAB14, member RAS oncogene family / P61106*  / reaction / complex
 ENSMUSG00000014550 Rbsn / Q80Y56 / Rabenosyn-5 / Q9H1K0* / rabenosyn, RAB effector*  / complex / reaction
 ENSMUSG00000019478 Rab4a / P56371 / Ras-related protein Rab-4A / P20338* / RAB4A, member RAS oncogene family*  / reaction / complex
 ENSMUSG00000020375 Rufy1 / Q8BIJ7 / RUN and FYVE domain-containing protein 1 / Q96T51* / RUN and FYVE domain containing 1*  / reaction / complex
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / complex
 ENSMUSG00000026867 Gapvd1 / Q6PAR5 / GTPase-activating protein and VPS9 domain-containing protein 1 / Q14C86* / GTPase activating protein and VPS9 domains 1*  / complex
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / complex
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex






 

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