ENSMUSG00000020132


Mus musculus

Features
Gene ID: ENSMUSG00000020132
  
Biological name :Rab21
  
Synonyms : P35282 / Rab21 / RAB21, member RAS oncogene family
  
Possible biological names infered from orthology : Q9UL25
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 115287084
Gene end: 115315594
  
Corresponding Affymetrix probe sets: 10372478 (MoGene1.0st)   1437741_at (Mouse Genome 430 2.0 Array)   1437742_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151464
Ensembl peptide - ENSMUSP00000020343
NCBI entrez gene - 216344     See in Manteia.
MGI - MGI:894308
RefSeq - NM_024454
RefSeq Peptide - NP_077774
swissprot - A0A1W2P6Z4
swissprot - P35282
swissprot - Q0PD35
Ensembl - ENSMUSG00000020132
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAB21ENSDARG00000100752Danio rerio
 RAB21ENSGALG00000010183Gallus gallus
 RAB21ENSG00000080371Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab31 / RAB31, member RAS oncogene family / Q13636*ENSMUSG0000005651541
Rab5a / Q9CQD1 / Ras-related protein Rab-5A / P20339* / RAB5A, member RAS oncogene family*ENSMUSG0000001783140
Rab5c / P35278 / RAB5C, member RAS oncogene family / P51148*ENSMUSG0000001917338
P35285 / Rab22a / RAB22A, member RAS oncogene family / Q9UL26*ENSMUSG0000002751938
Rab5b / P61021 / RAB5B, member RAS oncogene family / P61020*ENSMUSG0000000071137
Rab17 / P35292 / Ras-related protein Rab-17 / Q9H0T7* / RAB17, member RAS oncogene family*ENSMUSG0000002630435
Rab20 / P35295 / Ras-related protein Rab-20 / Q9NX57* / RAB20, member RAS oncogene family*ENSMUSG0000003150429
Q8CFP6 / Dnajc27 / DnaJ homolog subfamily C member 27 / Q9NZQ0* / DnaJ heat shock protein family (Hsp40) member C27*ENSMUSG0000002065728


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008089 anterograde axonal transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0017157 regulation of exocytosis IEA
 biological_processGO:0030100 regulation of endocytosis IBA
 biological_processGO:0030516 regulation of axon extension IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IMP
 biological_processGO:2000643 positive regulation of early endosome to late endosome transport IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0012506 vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0098559 cytoplasmic side of early endosome membrane IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0019003 GDP binding IEA


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / complex
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / complex
 ENSMUSG00000034867 Q3UMR0 / Ankrd27 / Ankyrin repeat domain-containing protein 27 / Q96NW4* / ankyrin repeat domain 27*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / complex
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex
 ENSMUSG00000036529 Sbf1 / Q6ZPE2 / SET binding factor 1 / O95248*  / reaction






 

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