ENSG00000080371


Homo sapiens

Features
Gene ID: ENSG00000080371
  
Biological name :RAB21
  
Synonyms : Q9UL25 / RAB21 / RAB21, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q21.1
Gene start: 71754874
Gene end: 71800285
  
Corresponding Affymetrix probe sets: 203885_at (Human Genome U133 Plus 2.0 Array)   226268_at (Human Genome U133 Plus 2.0 Array)   239329_at (Human Genome U133 Plus 2.0 Array)   241263_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261263
NCBI entrez gene - 23011     See in Manteia.
OMIM - 612398
RefSeq - NM_014999
RefSeq Peptide - NP_055814
swissprot - A0A024RBA9
swissprot - Q9UL25
Ensembl - ENSG00000080371
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAB21ENSDARG00000100752Danio rerio
 RAB21ENSGALG00000010183Gallus gallus
 Rab21ENSMUSG00000020132Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB31 / Q13636 / RAB31, member RAS oncogene familyENSG0000016846140
RAB5A / P20339 / RAB5A, member RAS oncogene familyENSG0000014456639
Q9UL26 / RAB22A / RAB22A, member RAS oncogene familyENSG0000012420938
RAB5C / P51148 / RAB5C, member RAS oncogene familyENSG0000010877438
RAB5B / P61020 / RAB5B, member RAS oncogene familyENSG0000011154036
RAB17 / Q9H0T7 / RAB17, member RAS oncogene familyENSG0000012483935
AC099811.2ENSG0000026726133
Q9NZQ0 / DNAJC27 / DnaJ heat shock protein family (Hsp40) member C27ENSG0000011513729
RAB20 / Q9NX57 / RAB20, member RAS oncogene familyENSG0000013983228


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008089 anterograde axonal transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0017157 regulation of exocytosis IDA
 biological_processGO:0030516 regulation of axon extension IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IMP
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IEA
 biological_processGO:2000643 positive regulation of early endosome to late endosome transport IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0012506 vesicle membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098559 cytoplasmic side of early endosome membrane IDA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IMP
 molecular_functionGO:0019003 GDP binding IDA


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex
 ENSG00000133812 SBF2 / Q86WG5 / SET binding factor 2  / reaction
 ENSG00000105186 Q96NW4 / ANKRD27 / ankyrin repeat domain 27  / reaction
 ENSG00000100241 SBF1 / O95248 / SET binding factor 1  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr