ENSG00000105186


Homo sapiens

Features
Gene ID: ENSG00000105186
  
Biological name :ANKRD27
  
Synonyms : ANKRD27 / ankyrin repeat domain 27 / Q96NW4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.11
Gene start: 32597007
Gene end: 32676597
  
Corresponding Affymetrix probe sets: 221522_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476897
Ensembl peptide - ENSP00000304292
Ensembl peptide - ENSP00000464751
Ensembl peptide - ENSP00000464819
Ensembl peptide - ENSP00000466138
Ensembl peptide - ENSP00000466905
Ensembl peptide - ENSP00000467447
NCBI entrez gene - 84079     See in Manteia.
RefSeq - XM_017027349
RefSeq - NM_032139
RefSeq - XM_006723412
RefSeq Peptide - NP_115515
swissprot - K7EPM2
swissprot - K7EIH4
swissprot - Q96NW4
swissprot - V9GYL8
swissprot - K7EIN0
swissprot - K7ENE0
swissprot - K7ELM1
Ensembl - ENSG00000105186
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ankrd27ENSDARG00000089207Danio rerio
 ANKRD27ENSGALG00000004671Gallus gallus
 Q3UMR0ENSMUSG00000034867Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRPA1 / O75762 / transient receptor potential cation channel subfamily A member 1ENSG0000010432113


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR003123  VPS9 domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037191  VPS9 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0035544 negative regulation of SNARE complex assembly IDA
 biological_processGO:0035646 endosome to melanosome transport IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045022 early endosome to late endosome transport IDA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1990126 retrograde transport, endosome to plasma membrane IMP
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0097422 tubular endosome IDA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0017137 Rab GTPase binding IEA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction
 ENSG00000080371 RAB21 / Q9UL25 / RAB21, member RAS oncogene family  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction






 

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