ENSG00000104321


Homo sapiens

Features
Gene ID: ENSG00000104321
  
Biological name :TRPA1
  
Synonyms : O75762 / transient receptor potential cation channel subfamily A member 1 / TRPA1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q21.11
Gene start: 72019917
Gene end: 72075617
  
Corresponding Affymetrix probe sets: 208349_at (Human Genome U133 Plus 2.0 Array)   217590_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262209
Ensembl peptide - ENSP00000428151
NCBI entrez gene - 8989     See in Manteia.
OMIM - 604775
RefSeq - XM_017013946
RefSeq - NM_007332
RefSeq - XM_011517624
RefSeq - XM_011517625
RefSeq Peptide - NP_015628
swissprot - H0YAW0
swissprot - O75762
Ensembl - ENSG00000104321
  
Related genetic diseases (OMIM): 615040 - ?Episodic pain syndrome, familial, 1, 615040
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpa1aENSDARG00000016699Danio rerio
 trpa1bENSDARG00000031875Danio rerio
 TRPA1ENSGALG00000034751Gallus gallus
 Trpa1ENSMUSG00000032769Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96NW4 / ANKRD27 / ankyrin repeat domain 27ENSG0000010518612


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR005821  Ion transport domain
 IPR020683  Ankyrin repeat-containing domain
 IPR030288  Transient receptor potential cation channel subfamily A member 1
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport TAS
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0010033 response to organic substance IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0048265 response to pain IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0050955 thermoception IEA
 biological_processGO:0050966 detection of mechanical stimulus involved in sensory perception of pain IEA
 biological_processGO:0050968 detection of chemical stimulus involved in sensory perception of pain IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032421 stereocilium bundle IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0015267 channel activity IEA
 molecular_functionGO:0015278 calcium-release channel activity IMP
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0097604 temperature-gated cation channel activity IDA


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0003593 Early onset 
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 HP:0012531 Pain "An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage." [ORCID:0000-0001-5208-3432]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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