ENSG00000203668


Homo sapiens

Features
Gene ID: ENSG00000203668
  
Biological name :CHML
  
Synonyms : CHML / CHM like, Rab escort protein 2 / P26374
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q43
Gene start: 241628853
Gene end: 241640254
  
Corresponding Affymetrix probe sets: 1565947_a_at (Human Genome U133 Plus 2.0 Array)   1565949_x_at (Human Genome U133 Plus 2.0 Array)   1565951_s_at (Human Genome U133 Plus 2.0 Array)   1566337_x_at (Human Genome U133 Plus 2.0 Array)   206079_at (Human Genome U133 Plus 2.0 Array)   226350_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355511
Ensembl peptide - ENSP00000490694
Ensembl peptide - ENSP00000490433
Ensembl peptide - ENSP00000490147
NCBI entrez gene - 1122     See in Manteia.
OMIM - 118825
RefSeq - NM_001821
RefSeq Peptide - NP_001812
swissprot - A0A1B0GVA4
swissprot - A0A1B0GUK6
swissprot - A0A1B0GVX9
swissprot - P26374
Ensembl - ENSG00000203668
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chmENSDARG00000003845Danio rerio
 CHMENSGALG00000006906Gallus gallus
 ChmlENSMUSG00000078185Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHM / P24386 / CHM, Rab escort protein 1ENSG0000018841970
GDI2 / P50395 / GDP dissociation inhibitor 2ENSG0000005760817
GDI1 / P31150 / GDP dissociation inhibitor 1ENSG0000020387917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001738  Rab protein geranylgeranyltransferase component A
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR018203  GDP dissociation inhibitor
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0018344 protein geranylgeranylation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005968 Rab-protein geranylgeranyltransferase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005092 GDP-dissociation inhibitor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IPI


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111737 RAB35 / Q15286 / RAB35, member RAS oncogene family  / complex
 ENSG00000100949 Q92696 / RABGGTA / Rab geranylgeranyltransferase alpha subunit  / reaction / complex
 ENSG00000105649 RAB3A / P20336 / RAB3A, member RAS oncogene family  / complex
 ENSG00000100599 RIN3 / Q8TB24 / Ras and Rab interactor 3  / reaction
 ENSG00000107036 RIC1 / Q4ADV7 / RIC1 homolog, RAB6A GEF complex partner 1  / reaction
 ENSG00000127328 Q96QF0 / RAB3IP / RAB3A interacting protein  / reaction
 ENSG00000118873 Q9H2M9 / RAB3GAP2 / RAB3 GTPase activating non-catalytic protein subunit 2  / reaction
 ENSG00000213047 Q6P3S1 / DENND1B / DENN domain containing 1B  / reaction
 ENSG00000115839 Q15042 / RAB3GAP1 / RAB3 GTPase activating protein catalytic subunit 1  / reaction
 ENSG00000165219 GAPVD1 / Q14C86 / GTPase activating protein and VPS9 domains 1  / reaction
 ENSG00000080371 RAB21 / Q9UL25 / RAB21, member RAS oncogene family  / complex
 ENSG00000075785 RAB7A / P51149 / RAB7A, member RAS oncogene family  / complex
 ENSG00000105339 A2RUS2 / DENND3 / DENN domain containing 3  / reaction
 ENSG00000108953 YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon  / reaction
 ENSG00000133812 SBF2 / Q86WG5 / SET binding factor 2  / reaction
 ENSG00000084733 RAB10 / P61026 / RAB10, member RAS oncogene family  / complex
 ENSG00000174839 Q8IWF6 / DENND6A / DENN domain containing 6A  / reaction
 ENSG00000110514 MADD / Q8WXG6 / MAP kinase activating death domain  / reaction
 ENSG00000164077 MON1A / Q86VX9 / MON1 homolog A, secretory trafficking associated  / reaction
 ENSG00000146966 Q9ULE3 / DENND2A / DENN domain containing 2A  / reaction
 ENSG00000167461 RAB8A / P61006 / RAB8A, member RAS oncogene family  / complex
 ENSG00000105186 Q96NW4 / ANKRD27 / ankyrin repeat domain 27  / reaction
 ENSG00000175582 RAB6A / P20340 / RAB6A, member RAS oncogene family  / complex
 ENSG00000144566 RAB5A / P20339 / RAB5A, member RAS oncogene family  / complex
 ENSG00000167994 Q8TBN0 / RAB3IL1 / RAB3A interacting protein like 1  / reaction
 ENSG00000069974 P51159 / RAB27A / RAB27A, member RAS oncogene family  / complex
 ENSG00000100099 HPS4 / Q9NQG7 / HPS4, biogenesis of lysosomal organelles complex 3 subunit 2  / reaction
 ENSG00000137955 P53611 / RABGGTB / Rab geranylgeranyltransferase beta subunit  / complex / reaction
 ENSG00000184014 Q6IQ26 / DENND5A / DENN domain containing 5A  / reaction
 ENSG00000107521 HPS1 / Q92902 / HPS1, biogenesis of lysosomal organelles complex 3 subunit 1  / reaction
 ENSG00000122674 CCZ1 / P86791 / CCZ1 homolog, vacuolar protein trafficking and biogenesis associated  / reaction
 ENSG00000206418 RAB12 / Q6IQ22 / RAB12, member RAS oncogene family  / complex
 ENSG00000170456 Q6ZUT9 / DENND5B / DENN domain containing 5B  / reaction
 ENSG00000100241 SBF1 / O95248 / SET binding factor 1  / reaction
 ENSG00000137145 Q5VZ89 / DENND4C / DENN domain containing 4C  / reaction
 ENSG00000198837 O75064 / DENND4B / DENN domain containing 4B  / reaction
 ENSG00000099246 RAB18 / Q9NP72 / RAB18, member RAS oncogene family  / complex
 ENSG00000119522 Q8TEH3 / DENND1A / DENN domain containing 1A  / reaction
 ENSG00000118508 RAB32 / Q13637 / RAB32, member RAS oncogene family  / complex
 ENSG00000123892 RAB38 / P57729 / RAB38, member RAS oncogene family  / complex
 ENSG00000179331 Q14964 / RAB39A / RAB39A, member RAS oncogene family  / complex
 ENSG00000123595 RAB9A / P51151 / RAB9A, member RAS oncogene family  / complex
 ENSG00000143545 RAB13 / P51153 / RAB13, member RAS oncogene family  / complex
 ENSG00000119396 RAB14 / P61106 / RAB14, member RAS oncogene family  / complex
 ENSG00000205744 Q8IV53 / DENND1C / DENN domain containing 1C  / reaction
 ENSG00000107185 RGP1 / Q92546 / RGP1 homolog, RAB6A GEF complex partner 1  / reaction
 ENSG00000138069 RAB1A / P62820 / RAB1A, member RAS oncogene family  / complex
 ENSG00000205593 Q8NEG7 / DENND6B / DENN domain containing 6B  / reaction
 ENSG00000174485 Q7Z401 / DENND4A / DENN domain containing 4A  / reaction
 ENSG00000168461 RAB31 / Q13636 / RAB31, member RAS oncogene family  / complex






 

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